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Light Microscopy – News and Features

Fluorescent shapes.

Revolutionary “Disco” Technique Maps Entire Bodies of Mice

Researchers developed a new method called wildDISCO that uses standard antibodies to map the entire body of an animal using fluorescent markers. This revolutionary technique provides detailed 3D maps of structures, shedding new light on complex biological systems and diseases.
An image taken of brain tissue.

Novel Imaging Technology Provides a 'Live' View Into the Brain’s Complexity

The new imaging and virtual reconstruction technology developed at ISTA is a big leap in imaging brain activity and is aptly named LIONESS – Live Information Optimized Nanoscopy Enabling Saturated Segmentation.
A close-up photograph of a microscope looking at a glass slide

New Combination of Imaging Techniques Could Revolutionize Microscopy

Researchers have developed a new microscopy technique that allows scientists to simultaneously observe single molecules and read their chemical information.
A person holding a handful of wheat above an expansive crop field

Researchers Propose New Method To Identify Label-Free Microplastics in Crop Plants

Hyperspectral-enhanced dark field microscopy can be used to detect label-free microplastics, researchers have found. This method completely avoids the interference caused by the shed of microplastic markers.
Lung epithelial cell line with membranes and nuclei stained in red and blue.

New Tool Developed To Study Viral Infections

Researchers have developed a new tool that can identify cells that are actively responding to a SARS-CoV-2 infection and can be used to screen for effective COVID-19 therapies.
A connective tissue cell in which the adhesion protein talin has been modified.

New Method for Examining Mechanical Processes in Cells Developed

Researchers at the University of Münster have developed a method for altering the mechanics of individual molecules and thereby investigating their function within the cells.
A spider web covered in a light dew

Scientists Are One Step Closer To Replicating Spider Silk

For the first time, researchers have been able to study the internal workings of unprocessed spider silk. This additional data could help further the production of synthetic fibers strong enough to replace materials like Kevlar or carbon fiber.
Image of lung cancer cells under the microscope, taken from a mouse model.

New Biomarkers Identified For the Most Common Lung Cancer

The study notes that certain features of the collagen fibers could be a potential indicator for the diagnosis and prediction of the evolution of the disease.
A COVID-19 protein.

Cholesterol Open the Door Into Our Cells for COVID To Slip In

A recent study unveiled the doorway that SARS-CoV2 uses to slip inside cells undetected.
Neuron cells connected.

Understanding Cellular Mechanisms Within the Retina

A study has uncovered novel cellular mechanisms within the retina, findings that could help advance the development of targeted therapeutics for diseases and conditions impacting vision.