Liquid Biopsies – Multimedia

An analogy of finding CTCs: Imagine you have three friends, and they are somewhere in Canada. But you don't know where they are. Also, they change their clothes and hair colour every day.
Watch to learn about this liquid biopsy test that has successfully progressed from the research lab to the clinic.

Dr. Jeffrey Trent and Dr. Muhammad Murtaza of TGen, an affiliate of City of Hope, discuss the significance of liquid biopsies in the diagnoses and management of life-threatening diseases.

In this list we take a look at 6 researchers whose contributions have helped (and are continuing to help) drive the field forward.

This article highlights some of the wide range of applications which can be achieved using mass spectrometry.

Our objective is to validate diagnostic services using Oxford Nanopore’s Minion in the first instance and to evaluate the cost and performance compared to existing sequencing technology in areas such as tumour DNA sequencing (and circulating tumour DNA), virology, microbiology, genetics and HLA-typing.

We developed a magnetic bead-based cfDNA extraction kit and integrated it into the automated qPCR- and NGS-based IVD workflows. In this study we are compering this magnetic beads-based cfDNA extraction system with a column-based method.

Liquid biopsy provides a circulating biomarker not only for treatment response but decision making of a sequential strategy.

Seth Crosby, Washington University School of Medicine, discusses both bench and informatic methods used to increase specificity in the apprehension of rare cfDNA alleles.

Jeff Cummings presents a worked example of circulating tumour cell enumeration as a prognostic/predictive biomarker in cancer research.

Paramagnetic Dynabeads® magnetic beads provide a versatile, automation friendly tool for fast sensitive and high throughput isolation that can be tailored to isolate specific circulating biomarkers such as cells, exosomes and nucleic acids.