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Neurogenomics – News and Features

A purple human brain.
News

Gene Delivery Vehicle Shows Promise for Human Gene Therapy

Scientists have engineered an adeno-associated virus (AAV) that efficiently crosses the blood-brain barrier in human cell models and delivers genes throughout the brain in humanized mice.
Neurodegeneration.
News

Researchers Identify Symptom-Free Alzheimer’s Patients

Researchers looked at brains from the Netherlands Brain Bank. The team found a subgroup of people who had Alzheimer’s disease processes in their brains, but did not show any clinical symptoms while alive.
Neurons that are degenerating.
News

Rapid Cell Aging Discovered in Certain Brain Cells Linked to Alzheimer’s

Engineers at the University of California San Diego have discovered that some brain cells age more rapidly than others, and they are disproportionately abundant in individuals afflicted with Alzheimer’s disease.
The shape of a brain in bright star shapes.
News

Engineers Create a New Method To Detect Light Deep in the Brain

A new method to label cells deep within the brain has been developed.
A purple human brain.
News

New Biomarkers Could Help Diagnosis of Schizophrenia in Rare Genetic Disorder

A recent study led by UC Davis Health researchers provides new insights into the molecular changes linked to the rare genetic condition 22q11.2 deletion syndrome, or 22q.
Dr. Sarah Teichmann standing next to a building and pond.
Article

From School Science Club to Cell Atlasing With Dr. Sarah Teichmann

In this interview, Dr. Sarah Teichmann shares insights into her research interests, the goals and progress of the HCA to date, as well as her thoughts on how women can begin and build successful careers in science.
A bright image depicting neuronal connections.
News

BARSeq Reveals the Brain Is Like a Pointillism Painting

BARseq, a high-throughput sequencing method, allows scientists to read and localize RNA barcodes in situ. In a new Nature study, researchers from the Allen Institute for Brain Science applied BARseq to explore how peripheral inputs shape the cellular composition of cortical neurons.
A person sits next to a pile of photographs.
News

Memory Formation Mechanism Requires DNA Flexibility

Researchers have uncovered a novel mechanism underlying memory formation that involves rapid changes to DNA structure.
A girl sat alone in a room looking out a window.
News

Study Identifies Genetic Roots of PTSD

Findings from the largest genetic study of PTSD to date could help explain why only some people develop the condition after experiencing trauma.
High magnification micrograph of microglia cells stained with Rio-Hortega's method (silver carbonate). This type is the ramified or resting microglia that appears in normal brain tissue.
News

Mobilizing Microglia in the Fight Against Alzheimer’s Disease

Recently approved Alzheimer's drugs work by tagging amyloid plaques for clearance by the brain's microglia. Washington University School of Medicine in St. Louis researchers are developing an alternative approach, using a homemade antibody to directly mobilize microglia.
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