Next-Generation Sequencing – News and Features

Researchers analyzed human remains from the Oakhurst rock shelter in southernmost Africa and reconstructed the genomes of thirteen individuals, who died between 1,300 and 10,000 years ago.

A new method analyzes wastewater to identify sources of harmful bacteria and antimicrobial resistance. The study enhances understanding of urban health risks and supports public health efforts to prevent disease outbreaks.

Single-cell analysis offers a unique perspective of the genetic and molecular features of individual cells. In this article, two early adopters of single-cell analysis technologies highlight some of the latest advances and new applications.

This article examines how next-generation sequencing and state-of-the-art imaging technologies are being combined to characterize and map the spatial organization of cell types in tissues.

New research has found four genes with some of the largest known effects on the timing of menopause discovered to date, providing new insight into links between menopause timing and cancer risk.

A biomarker of eight microRNAs forms a "fingerprint" of ALS in the blood, which can be detected with 98% accuracy in a diagnostic test.

A study by ISGlobal and collaborators found that air samples taken at 1,000-3,000 meters above Japan contained diverse, viable bacteria and fungi, some pathogenic. These microbes, likely transported from fertilizer-rich areas in China.

Researchers have created an intricate molecular map of the human body and its complex physiological processes based on the analysis of thousands of molecules measured in blood, urine and saliva samples from 391 volunteers.

Air samples taken at altitudes up to 3,000 meters over Japan unveil the presence of a wide array of microbes, some of which are potentially pathogenic to humans, transported thousands of kilometers by aerosols originating in northeast China.

Scientists at RIKEN have identified chromosomal and gene expression changes that lead to stem cell exhaustion in aging fruit flies. This study reveals that chromatin structure changes block gene expression, contributing to stem cell depletion.