Next-Generation Sequencing – News and Features

Researchers have demonstrated that characterizing genetic material near chromosomes forecasts how mutated, cancer-causing genes reengineer DNA and alter the tumor microenvironment.

A study shows how a class of drugs, HDACi (histone deacetylase inhibitors), protects neurons and limits brain damage following stroke by altering the gene expression of microglia, the immune cells of the brain.

This article explores how next-generation sequencing has revolutionized microbiome research, enabling comprehensive analysis of microbial communities and their roles in health and disease.

A study found that exercise alters brain cell activity in Alzheimer’s disease, specifically in microglia and newly discovered neurovascular-associated astrocytes. The findings offer a roadmap for future Alzheimer’s therapies.

Human papillomavirus can drive tumor development in some rare sinonasal squamous cell carcinomas, according to a new comprehensive study of these tumors.

A study suggests that individuals with less diverse oral microbiomes are more likely to report symptoms of depression. The research highlights the potential link between oral health and mental well-being.

A new spatial transcriptomics analysis resource is helping scientists explore how genes behave differently in various parts of the body. This could help to zero in on exact biological processes that could be targeted to treat disease.

A new method combines microscopy with single-cell RNA analysis to make the technique more accessible and scalable, giving researchers an advantage in the numbers game of single-cell analysis.

Researchers have created 63 genetically engineered mouse stem cell lines to study autism-related mutations, especially copy number variations (CNVs). The library reveals shared protein production issues across different autism mutations.

Scientists have identified the discrete group of co-activated neurons in the brain that work to suppress binge drinking behaviors. This could become a new therapeutic target for alcohol dependency.