Next-Generation Sequencing – News and Features

New research uncovers how the brain, immune system, and nervous system contribute to heart attack damage, revealing three nodes that could be targeted with new therapeutics.

Industry experts predict that proteomics’ next frontier lies in multiomics integration, AI-driven analysis, clinical scalability, and broader accessibility. Companies are preparing by improving assay robustness and reducing costs.

Researchers identified miR-149-5p as overexpressed in progressive bronchial premalignant lesions. The microRNA suppresses NLRC5 and immune recognition genes, reducing immune cell proximity to abnormal airway cells.

Realistic quantum-mechanical simulations demonstrate that TERS images reflect surface electronic response as much as atomic displacement. The work improves interpretation of nanoscale vibrational maps.

Researchers analyzed more than 200 immune traits in 246 calves, linking genetic variation, season, and age to immune responses. The findings support breeding strategies to enhance natural disease resistance.

The study reveals that hippocampal microglia actively regulate adult neurogenesis. When TGF-beta signaling is absent, activated microglia stimulate neural stem cells, and highlighting immune control of neuron formation.

Researchers found that distinct tumor clones in uveal melanoma determine where metastases form. Clones with BAP1 mutations preferentially spread to the liver and providing genetic evidence for organ-specific metastasis.

Researchers identified multiple gene signatures linked to psoriasis severity, body weight, and immune activity. These biomarkers may help predict treatment response and support more tailored approaches to managing the chronic inflammatory disease.

In this interview, Technology Networks spoke to Dr. Funda Meric-Bernstam about the landscape of personalized cancer therapy.

Do microorganisms truly reside in tumors, or do the samples become contaminated before sequencing occurs? A new computational tool settles the controversy by distinguishing genuine microbial signals from artifacts.