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Next-Generation Sequencing – News and Features

A cross section of a string of protein travelling through a pore.

Protein Successfully Transported Through a Nanopore

A new technology where a protein passes through a nanopore could be the key to easy protein sequencing.
A trace of Sanger sequencing data generated using capillary electrophoresis with a pen paying on the top.

An Introduction to Capillary Electrophoresis: Theory, Practice and Applications

Capillary electrophoresis is a powerful separation and analysis technique that offers quick and efficient results. In this article, we explore how it works, variations on the technique and their applications.
A blue butterfly perches on a white rock.

1,000 Species Get Their Genomes Sequenced for the First Time

1,000 reference genomes of the highest quality have now been produced for diverse eukaryotic species across the tree of life, as part of a project from the Sanger Institute.
DNA strands.

A Step Forward in Our Understanding of the Genetic Basis of Schizophrenia

In a new study into the genetic variants associated with the development of schizophrenia, researchers used a genetic sequencing technique that can parse which variants trigger gene expression and which ones do not.
A small carpenter bee on a stem.

Maternal Care Influences Wild Bees' Microbiome and Health

Most wild bees are solitary, but one tiny species of carpenter bees fastidiously cares for and raises their offspring, an act that translates into huge benefits to the developing bee’s microbiome, development and health.
A doctor in scrubs shows a patient a tablet.

Inflated Risks From Genetic Testing Could Lead to Unnecessary Breast Surgery

Women could be opting to have unnecessary surgery to avoid breast cancer, after being told they are at high risk from genetic test results which do not take family history into account.
A woman breastfeeding an infant.

Early-Stage Breast Cancers Detected From Breastmilk

Researchers have shown for the first time that breast milk from breast cancer patients contains tumor DNA, known as circulating tumor DNA (ctDNA). This can be detected through liquid biopsy in breast milk.
Keys with the DNA bases written on them in a random order.

Understanding Bacteria on an Individual Level

Recently, scientists have begun leveraging next-generation sequencing and associated techniques, such as single-cell RNA sequencing, that researchers can use to study gene expression in hundreds of thousands of individual cells simultaneously.
Baby feet poking out from under a white towel.

Could Genomic Sequencing Be the Key to Improving Neonatal Health?

Recent advancements in genetic sequencing are a potential game-changer for newborn screening, swiftly assessing a comprehensive range of monogenic disorders. Yet, the effectiveness of genetic sequencing as an alternative method has not been studied.
Confocal image of a CHOOSE (CRISPR-human organoids-scRNA-seq) human brain.

How Human Brain Organoids Are Uncovering the Cause of Autism

With a revolutionizing novel system that combines brain organoid technology and intricate genetics, researchers can now comprehensively test the effect of multiple mutations in parallel and at a single-cell level within human brain organoids.