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Next-Generation Sequencing – News and Features

A clinician holds the results of a brain scan.

Developing a Personalized Vaccine Against Cancerous Brain Tumors

Pairing a personalized dendritic cell vaccine with an immune-boosting compound improves the immune response to malignant gliomas.
A plastic model of human lungs, bisected to show the internal structures.

The Role of Iron in Allergic Asthma Could Be Targeted in Potential New Treatments

Iron drives inflammation in the lungs during an allergic asthma attack, presenting a target for new treatments.
A figure of a human with their organs highlighted.

Heat Waves Can Have Damaging Impact on Vital Organs

Researchers from the University of California, Irvine have found evidence of the molecular causes of the damaging impact heat stress causes on the gut, liver and brain in the elderly.
Double helix structure of DNA.

Mutation in the “Dark” Genome Alters Thyroid Regulation

A team of researchers have uncovered a genetic mutation in a non-coding region of DNA that alters the regulation of the thyroid, leading to a rare form of congenital thyroid abnormality.
Bacteria in the intestine.

How Gut Epithelial Cells Defend Against Deadly Diarrheal Infections

A study brings new understanding to how absorptive intestinal epithelial cells, or IECs, and T cells work together to defend the gut barrier.
Purple cancer cells swirl against dark normal cells.

“Starving Out” Lung Cancer Cells May Be a Promising Therapy

Starving out tumor cells may be a promising therapy for treatment-resistant lung cancer, reports a new study.
immunofluorescent staining shows a lymph node that has been significantly expanded in mice with the help of the biomaterial MPS-vaccine (on the right), next to a lymph node taken from non-treated control mice (on the left) at the same time post-vaccination.

Biomaterial Vaccine Enhances Lymph Node Expansion and Boosts Anti-Tumor Immunity

A biomaterial vaccine enhances and sustains lymph node expansion following vaccination, boosting anti-tumor immunity in an animal model.
A strand of DNA, with one section lit up.

Exploring the Microbiome Reveals Novel Treatments for Genetic Disorders

A new CRISPR-Cas9 molecule produced by a bacterium in the gut microbiome could have clinical potential to treat genetic diseases.
A scientist holding up a vial.

Genetics Cause Cerebral Palsy in a Quarter of Cases, Not Lack of Oxygen

The world’s largest study of cerebral palsy (CP) genetics has discovered genetic defects are most likely responsible for more than a quarter of cases in Chinese children, rather than a lack of oxygen at birth as previously thought.
Cancer cells.

Testing for Residual Cancer Cells Before Cell Transplant Therapy May Improve Outcomes

Research highlights the feasibility of testing for lingering cancer cells for patients in remission from a high-risk blood cancer, says Fralin Biomedical Research Institute at VTC Professor Christopher Hourigan.