Next-Generation Sequencing – News and Features

Our circadian clock doesn't just dictate when we sleep – it also determines how quickly our muscles heal, with muscle injuries healing faster when they occur during natural waking hours.

Immuno-oncology and cell-based treatments, which harness the body's own immune system to combat illnesses like cancer, have emerged as some of the most promising areas of study. This article explores how cell therapy is evolving.

Johns Hopkins and Cold Spring Harbor researchers discovered genes controlling fruit size in tomatoes and eggplants. Using CRISPR gene editing, they modified key genes to grow larger fruits.

A study using Genomics England’s 100,000 Genomes Project identified 69 new genetic variants linked to rare diseases, including kidney disease, diabetes and epilepsy. The findings could improve diagnoses and lead to new treatments.

Scientists from UCLA, the University of Toronto and the University of Melbourne have uncovered new genetic clues that explain why some prostate cancers remain slow-growing while others become life-threatening.

90% of people with obesity have leptin resistance – new research has found a mechanism involved and a way to reverse it using a well-known drug.

Colorectal cancer and pancreatic ductal adenocarcinoma that harbored the KRAS G12C mutation often carried other genetic alterations that can be associated with resistance to KRAS G12C inhibitors.

A study has demonstrated the impact of HiFi long-read sequencing (LRS) in identifying rare disease variants. These findings highlight the potential of HiFi LRS technology to replace multiple diagnostic tests with a single test.

The Gene Ontology Consortium has released a new resource mapping human gene functions using evolutionary modeling. The PAN-GO functionome integrates experimental data from humans and model organisms, enhancing biomedical research.

A deep-learning framework can support spatial transcriptomics techniques by integrating gene expression, spatial data and histological images to advance tissue analysis.