Next-Generation Sequencing – News and Features

Industry Insight
Why Good Science Is Key to Good Technology
In this opinion piece, Philipp Koellinger explores the changes required to level the playing field and accelerate both scientific and technological progress.

News
Long-Read Sequencing and AI Shed Light on DNA Replication
Combining long-read DNA sequencing with a predictive artificial intelligence model has provided new insights into DNA replication.

News
Genomics Data Reveals Microbial Diversity Hotspots
New research has taken stock of of the current state of microbial genomic biodiversity, finding diversity hotspots.

Industry Insight
How SPRQ Chemistry Is Breaking Barriers in DNA Sequencing
Dr. Aaron Wenger tells us about SPRQ chemistry, highlighting its unique benefits and role in expanding our understanding of rare diseases.

News
Rare Liver Cancer’s Unique Characteristics Identified
New insights into fibrolamellar hepatocellular carcinoma could lead to new drugs and significantly improved health outcomes.

News
Genetic Reanalysis Helps Diagnose Over 500 Patients
More than 500 European patients with unknown conditions have received a diagnosis through new genetic research.

News
Role of Rotavirus Protein in Gastrointestinal Disease Severity Revealed
Researchers revealed that the rotavirus NSP4 protein drives disease severity by disrupting calcium signaling in infected and nearby cells. These disruptions worsen symptoms and trigger immune responses.

News
HIV-1's Secret RNA Structures Offer Clues for Fighting the Virus
Researchers mapped HIV-1’s translation strategy, revealing RNA elements like uORFs, iORFs and an intricate frameshift site structure that regulate viral protein synthesis. These findings highlight ribosome pausing as a key mechanism.

News
Infection-Triggered Autoimmune Disease Driven by Mutations in “Rogue” Immune Cells
Garvan Institute researchers discovered how chronic hepatitis C virus (HCV) infections lead to autoimmune diseases like cryoglobulinemic vasculitis. By identifying rogue B cell clones caused by persistent antibody clustering and mutations.

News
Microbiome Changes Reveal Risk for Sexually Transmitted Disease
A study involving Black and Hispanic women identified two BV subtypes, with one significantly raising chlamydia risk. Advanced microbiome analysis linked specific bacterial imbalances to subsequent chlamydia infections.
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