Next-Generation Sequencing – News and Features

New research has taken stock of of the current state of microbial genomic biodiversity, finding diversity hotspots.

Dr. Aaron Wenger tells us about SPRQ chemistry, highlighting its unique benefits and role in expanding our understanding of rare diseases.

New insights into fibrolamellar hepatocellular carcinoma could lead to new drugs and significantly improved health outcomes.

More than 500 European patients with unknown conditions have received a diagnosis through new genetic research.

Researchers revealed that the rotavirus NSP4 protein drives disease severity by disrupting calcium signaling in infected and nearby cells. These disruptions worsen symptoms and trigger immune responses.

Researchers mapped HIV-1’s translation strategy, revealing RNA elements like uORFs, iORFs and an intricate frameshift site structure that regulate viral protein synthesis. These findings highlight ribosome pausing as a key mechanism.

Garvan Institute researchers discovered how chronic hepatitis C virus (HCV) infections lead to autoimmune diseases like cryoglobulinemic vasculitis. By identifying rogue B cell clones caused by persistent antibody clustering and mutations.

A study involving Black and Hispanic women identified two BV subtypes, with one significantly raising chlamydia risk. Advanced microbiome analysis linked specific bacterial imbalances to subsequent chlamydia infections.

A study reveals how Salmonella enterica leverages a small RNA, ManS, to regulate Neu5Ac metabolism and adapt to the host intestine. ManS originates from the 3′ UTR of mRNA via noncanonical RNase III cleavage.

A new study has lifted the lid on five species of root-lesion nematodes living in maize crops across New Zealand and suggested the existence of a hitherto-unsuspected cryptic species.