Next-Generation Sequencing – News and Features

New genomic data has illustrated that Armenians are not descended from settlers from the Balkans, debunking Herodotus' theory.

University of Copenhagen researchers uncovered how juvenile hormone regulates caste differentiation in pharaoh ants. By treating worker larvae with the hormone, researchers induced queen-like traits.

Researchers have revealed how IDH mutations in gliomas act as a "ticking time bomb," initiating slow growth before genetic mutations drive aggressive cancer progression. The study highlights epigenetic immune suppression and cellular shifts.

UCLA researchers have developed a new approach to treating glioblastoma by combining genetic and functional profiling to predict tumor responses to therapies. The team showed promising results in tumor shrinkage.

Standardized tissue handling is crucial in cancer research, ensuring the preservation of sample integrity and data quality. This enables comprehensive analysis and enhances understanding of cancer biology, aiding therapeutic discoveries.

Researchers mapped gene expression across the mouse intestine, revealing its stability and adaptability to changes like inflammation. The study identified immune-controlled regions and resilient spatial patterns.

Researchers have used whole-genome CRISPR interference screening to identify the “Achilles Heel” of drug-resistant tuberculosis and identify drugs that target these weaknesses to rapidly kill drug-resistant strains.

A thymus atlas reveals that immune foundations are set as early as 12 weeks post-conception. Researchers uncovered key T cell development processes, offering insights for engineering immune cells to treat cancer and autoimmune diseases.

A study reveals that 3% of normal breast cells in healthy women have chromosomal abnormalities linked to invasive breast cancer, challenging current cancer detection methods. Aneuploid cells accumulate with age and mimic invasive cancer profiles.

T-cell dysfunction linked to obesity prevents T cells from detecting tumor cells, increasing cancer risk.