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Next-Generation Sequencing – News and Features

Illustration of a human form

Dissecting the Proteome To Understand Disease

Proteomics provides insights into the regulation of biological processes and mechanisms of disease. In this article, we explore approaches scientists are using to find early markers of disease, new drug targets and strategies to overcome resistance to treatments.
A bright image depicting neuronal connections.

BARSeq Reveals the Brain Is Like a Pointillism Painting

BARseq, a high-throughput sequencing method, allows scientists to read and localize RNA barcodes in situ. In a new Nature study, researchers from the Allen Institute for Brain Science applied BARseq to explore how peripheral inputs shape the cellular composition of cortical neurons.
Multimodal analyses of cells from abnormal tunnels in Crohn's disease converge to illuminate underlying pathomechanisms.

Single-Cell Analysis Reveals Mechanism of Common Crohn’s Disease Complication

Study identifies key pathways underlying perianal fistula, a complication that is more prevalent and severe in African American populations.
Blue and white jellyfish.

Animal Bioluminescence Evolved 540 Million Years Ago

Bioluminescence first evolved in animals at least 540 million years ago in a group of marine invertebrates called octocorals, according to the results of a new study.
Zebrafish swim in an aquarium.

Zebrafish Immune System Linked to Ability To Regenerate Damaged Heart Tissue

A heart attack will leave a permanent scar on a human heart, yet other animals, including zebrafish, can clear cardiac scar tissue and regrow damaged muscle. A new study sheds light on the molecular and cellular mechanisms at play in this regeneration.
Purple virions on a pink background.

Researchers Identify Monkeypox Virus Genomic Changes Associated With Transmissibility

Genomic variations in the monkeypox virus genome have been identified that may be the cause of increased transmissibility.
Oak tree on a white background.
Industry Insight

Sequencing Life To Conserve Biodiversity

Neil Ward tells us about the role that genomics can play in conserving biodiversity and how innovative technologies such as HiFi sequencing are helping biodiversity projects.
Gloved hand of a lab worker holding four test tubes of blood.

Extended Blood Typing Needed for Improving Transfusion Safety

Explore how high-throughput DNA-based genotyping can offer a cost-effective way to screen extended blood types.
Fluorescence microscopy images of vpCell Pools.

Novel Method Allows Simultaneous Fluorescent Labeling of Many Proteins

Observing proteins precisely within cells is extremely important for many branches of research but has been a significant technical challenge. A research group has now overcome this hurdle: With a novel method.
Dr. Khadijah A. Mitchell

Cancer Research, Mentorship and Confidence in Your Competence With Dr. Khadijah A. Mitchell

Cancer researcher Dr. Khadijah A. Mitchell reflects on her journey into studying health disparities, touches on the importance of mentorship and shares some inspiring advice for women and girls considering a career in STEMM.