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Pharmacovigilance – Multimedia


Role of Sulfotransferases in Drug Metabolism and Potential for Drug Drug Interactions

Continuing our series on non-CYP-mediated metabolism pathways, we will be discussing another of the most requested enzymes: Sulfotransferases (SULTs). SULTs participate in Phase 2 metabolism of xenobiotics in humans and are characterized by the abundance and broad tissue distribution of the enzymes. Gene regulation and genetic polymorphism of SULTs also contribute to our understanding of the significance of these enzymes in the process of drug development.

Mitochondrial Toxicity in Drug Discovery

Download this infographic to learn more about mitochondrial toxicity and the novel solutions available for its identification in drug discovery.

Next-Generation Analytical Solutions for Cell and Gene Therapy

In medicine, gene therapy is the process where nucleic acids are delivered to a patient’s cells as a therapeutic drug to treat an array of genetic diseases. All gene therapies utilize either viral or non-viral vectors to deliver the DNA or RNA into the host cell.

Assessing Kinetics in Drug Discovery

Download this listicle to learn more about the importance of drug kinetics, key experimental techniques and computational modeling tools.

Addressing Unique Challenges With Custom In Vitro Test Systems

In this webinar, Products Director and custom test system expert, Zell Woodworth, will discuss some of the unique challenges his team have solved and the ways custom solutions are designed and executed to help researchers and drug developers meet goals outside the reach of standard in vitro products.

Recent Developments in Proteomics Research

Here, we take a closer look at some recent developments in the world of proteomics research.

A Vision Engaging Pharmacokinetic Strategies To Treat Substance Abuse Disorders and Overdose

This video lecture will detail the chemistry, immunology and behavioral findings from vaccines against opioids, including heroin and the synthetic opioids fentanyl and carfentanil, as well as a bacterial source to treat nicotine substance disorders and poisoning.

Eliminating Problems in Drug Development: Understanding the Role of Drug Metabolism

This talk will discuss processes for the metabolism of a drug, referred to as ADME (Absorption, Distribution, Metabolism, Excretion), and the safety testing to provide requisite information to move a drug through IND and into clinical trials. Prior to marketing a new drug and actually prior to administering a candidate drug to humans in clinical trials, it is important to ensure that drug will not only be effective in the therapeutic manner prescribed, but also be safe and not bring any undo harm to patients.

Shape-Morphing Microrobots Deliver Drugs to Cancer Cells

Delivering drugs directly to cancer cells could help reduce the unpleasant side effects of chemotherapy.

The Important Role of UDP Glucuronosyltransferases in Drug Metabolism and Drug–Drug Interactions

The importance of glucuronidation for metabolism of xenobiotics in humans is illustrated by the abundance and broad tissue distribution of the enzymes, the diversity of substrates and reactions catalyzed, as well as a number of distinctive UGT enzymes and their genetic polymorphisms.