Pharmacovigilance – Multimedia
Video
Some Sugar Free Gummy Bears Are Laxatives. No, Really
Sugar free gummies are delicious, low on calories, and… technically laxatives? Reactions producer Andrew dives into the science to figure out how he can make delicious sugar free gummies without the uncomfortable side effects.
Poster
In Vitro Approaches To Risk Assess Chemical-Mediated Changes in Thyroid Function
The hypothalamic-pituitary-thyroid axis (HPT axis) is conserved across vertebrate evolution. Perturbation of thyroid hormone homeostasis (THH) can lead to adverse effects in thyroid function affecting growth, metabolism and cognitive function.
App Note / Case Study
Comprehensive Characterization of O-Linked Glycosylation in Etanercept by Electron Activated Dissociation
Glycosylation is a common post-translational modification (PTM) that plays a critical role in antibody effector functions. Comprehensive characterization of N- and O-linked glycosylation in protein therapeutics is essential for ensuring drug safety and efficacy.
Video
Key Factors To Accelerate Drug Discovery
Speaking at Drug Discovery & Development online symposium 2021, Pei Liu from GenScript, presented her talk on monoclonal antibodies.
Listicle
Five Ways To Measure Immunotherapy Potency
This listicle highlights five commonly used cell viability assays and their benefits and limitations in immunotherapy potency testing.
How To Guide
Assessing Mitochondrial Toxicity in Early Drug Development
Mitochondrial toxicity assessments are crucial to ensuring the safety and efficacy of candidate compounds during drug development.
Video
Gene Therapy To Treat Epilepsy With Dr. Eric Wengert
In this Teach Me in 10 episode, Lucy Lawrence is joined by Dr. Eric Wengert, postdoctoral fellow at The Children’s Hospital of Philadelphia to discuss gene therapies used to treat epilepsy.
eBook
Evaluating Immune Cell Therapy Potency
Download this eBook to learn more about the tools available for evaluating immune cell therapy potency.
Video
Role of Sulfotransferases in Drug Metabolism and Potential for Drug Drug Interactions
Continuing our series on non-CYP-mediated metabolism pathways, we will be discussing another of the most requested enzymes: Sulfotransferases (SULTs). SULTs participate in Phase 2 metabolism of xenobiotics in humans and are characterized by the abundance and broad tissue distribution of the enzymes. Gene regulation and genetic polymorphism of SULTs also contribute to our understanding of the significance of these enzymes in the process of drug development.
Infographic
Mitochondrial Toxicity in Drug Discovery
Download this infographic to learn more about mitochondrial toxicity and the novel solutions available for its identification in drug discovery.
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