Pharmacovigilance – Multimedia

In medicine, gene therapy is the process where nucleic acids are delivered to a patient’s cells as a therapeutic drug to treat an array of genetic diseases. All gene therapies utilize either viral or non-viral vectors to deliver the DNA or RNA into the host cell.

Download this listicle to learn more about the importance of drug kinetics, key experimental techniques and computational modeling tools.

In this webinar, Products Director and custom test system expert, Zell Woodworth, will discuss some of the unique challenges his team have solved and the ways custom solutions are designed and executed to help researchers and drug developers meet goals outside the reach of standard in vitro products.

Here, we take a closer look at some recent developments in the world of proteomics research.

This video lecture will detail the chemistry, immunology and behavioral findings from vaccines against opioids, including heroin and the synthetic opioids fentanyl and carfentanil, as well as a bacterial source to treat nicotine substance disorders and poisoning.

This talk will discuss processes for the metabolism of a drug, referred to as ADME (Absorption, Distribution, Metabolism, Excretion), and the safety testing to provide requisite information to move a drug through IND and into clinical trials. Prior to marketing a new drug and actually prior to administering a candidate drug to humans in clinical trials, it is important to ensure that drug will not only be effective in the therapeutic manner prescribed, but also be safe and not bring any undo harm to patients.

Delivering drugs directly to cancer cells could help reduce the unpleasant side effects of chemotherapy.

The importance of glucuronidation for metabolism of xenobiotics in humans is illustrated by the abundance and broad tissue distribution of the enzymes, the diversity of substrates and reactions catalyzed, as well as a number of distinctive UGT enzymes and their genetic polymorphisms.

By recreating many of the cell-cell and cell-matrix interactions found in native tissues, spheroids and organoids provide more physiologically accurate models of disease and development than traditional 2D cultures.

Recently, the advantages of PHH liver spheroids use in liver toxicity tests over the traditional 2D monolayer culture of PHHs has been demonstrated by many scientists.