Pharmacovigilance – News and Features

The review explores how combining radiation and immunotherapy could improve outcomes by helping the immune system detect and destroy cancer cells more effectively.

Mass General Brigham researchers developed HPV-DeepSeek, a liquid biopsy blood test achieving 99% sensitivity for early detection of HPV-associated head and neck cancers. The test offers a highly accurate screening method.

Scientists have discovered that a promising new anticancer medicine currently in development could be made from unknown dangerous compounds. This discovery could overturn over 60 years of chemistry and almost 100 publications.

A group led by researchers at the A.C.Camargo Cancer Center has succeeded in improving CAR-T cells, making them more effective in treating refractory types of lymphoma and leukemia.

Duke University researchers have created SBI-810, an experimental compound that provides pain relief by selectively activating a specific receptor pathway, avoiding the typical side effects of opioids.

A study from NTNU reveals that JAK inhibitors, prescribed for autoimmune diseases like rheumatoid arthritis, may suppress the body’s antiviral defenses, making patients more vulnerable to viruses like influenza and SARS-CoV-2.

Oveporexton is an investigational oral orexin receptor 2-selective agonist designed to restore orexin signaling to address the underlying orexin deficiency that causes narcolepsy. Learn more about the results of the oveporexton Phase 2b trials.

In a world first, a child diagnosed with a rare metabolic disorder has been successfully treated with a customized CRISPR gene editing therapy.

Early results from a clinical trial suggest that while denosumab does not directly reduce the proliferation of breast cancer cells, it may enhance the body’s immune response against tumors.

A new meta-analysis has found that glucagon-like peptide 1 receptor agonists (GLP1- RAs) - a class of medications used to treat obesity and diabetes – may also offer benefits for emotional wellbeing in overweight users.