Psychedelics – News and Features

UC Davis researchers developed JRT, a modified version of LSD that promotes neuroplasticity without hallucinogenic effects. Tested in mice, JRT enhanced brain connectivity, showed antidepressant effects and improved cognition.

Cornell researchers found that psilocybin’s therapeutic benefits depend on the pyramidal tract neurons and the serotonin 5-HT2A receptor in the medial frontal cortex. Targeting these mechanisms could allow psilocybin to treat depression.

A study found that psychedelic experiences enhanced relationship quality, sexual attraction and intimacy. Participants reported both short- and long-term benefits, with some experiencing changes in gender identity.

A recent study challenges the effectiveness of microdosing LSD for treating ADHD. Despite self-reported improvements, the clinical trial found no significant difference between low-dose LSD and placebo in reducing ADHD symptoms.

A single dose of psilocin can induce changes in human nerve cells, providing researchers with a better understanding of the mechanisms behind psilocin's effects.

A Monash-led study evaluated MDMA-assisted psychotherapy (MDMA-AP) for PTSD, finding symptom improvement but low-certainty evidence. The findings will inform Australia’s first clinical guidelines on MDMA-AP.

Cold Spring Harbor Laboratory researchers confirm the existence of GluN1-2B-2D, a brain receptor targeted by ketamine. Using cryo-EM, they visualize how ketamine binds to the receptor, controlling its ion channel activity.

New research has made a breakthrough in understanding how our cells manage to stay healthy by recycling important fat molecules.

A new study finds that oral ketamine significantly reduces PTSD symptoms, with 73% of participants seeing a 50% reduction in symptoms. The treatment, taken as a liquid drink, was well-tolerated and had fewer side effects than intravenous ketamine.

The “magic mushroom” psychedelic compound – psilocybin – may help to improve mental health symptoms faced by cancer patients when used alongside psychotherapy.