Screening Strategies in Drug Discovery – Multimedia

During drug development initiatives, analysis of drug-target residence times can lead to improved efficacy. Therefore, residence times are increasingly being used to prioritize molecules early in lead discovery.

Fragment-based drug design has become an increasingly popular platform for the identification of lead candidates in drug discovery programs.

Today’s drug discovery strategies require candidate compounds to fail early and cheaply in the discovery stage, rather than late and expensively in the clinical phase. Testing compounds in physiologically relevant model systems and leveraging information from image-based screens are ways to focus on those compounds that give rise to the right phenotypic changes without undesirable effects on the system.

Since it is so closely related to the overall health of a cell and fundamentally involved in all of cell biology, the need for characterizing apoptosis and apoptotic processes occurs throughout the drug discovery process, from primary screening to toxicity profiling.

Accelerate drug discovery workflows with state-of-the art imaging and detection instruments, assay technologies, reagents, versatile automation systems, and powerful informatics solutions that work together to ensure consistent, accurate, physiologically relevant results. Wrest more meaning from your findings with PerkinElmer's one-of-a-kind analytics, and amplify your phenotypic or target-based screens to identify hits and lead compounds in small and focused or high-throughput volumes.

2017 has been an exciting year for the drug discovery field. This list details the top 10 most-read news stories we published from the field this year.

Magnetic – microcontact printing of extracellular matrix proteins (ECM) results in cell microarrays (CMA) showing homogeneous cell growth and attachment on defined patterns. This greatly reduces bias in the analysis of cell responses to toxins, drugs or other stimuli.

This list highlights four approaches used to assess toxicology within the field of drug discovery.

Technology trends can greatly increase the capabilities of the laboratory. Here we highlight some of the most popular upcoming trends in the field.

Automated robotic sample preparation with hyphenated dual LC-SWATH/MS analysis for lipids and polar metabolites.