Spatial Biology – News and Features

Professor Jennifer Van Eyk joined Technology Networks for an exclusive interview at HUPO 2024 to discuss progress and bottlenecks in clinical proteomics

University of Alabama researchers reveal a key mechanism in BK polyomavirus replication, challenging existing models. The virus relies on host cell DNA replication, with its TAg protein expressed only after the first replication round.

University of Michigan researchers identified UBA1 as a key player in immunotherapy resistance. Inhibiting UBA1 boosts T-cell recruitment, converting cold tumors to hot, and enhancing the effectiveness of immune checkpoint blockade therapies.

Researchers discovered that starlet sea anemones reshape their entire bodies during regeneration to maintain their original proportions. Using spatial transcriptomics, the team identified enzymes active throughout the body that realign tissues.

Researchers discovered that tumors grow uniformly throughout their mass, challenging the idea of faster growth at edges. Spatial genomics and simulations revealed evenly distributed mutations within tumors.

NYU Langone researchers found cancer cells resist chemotherapy in low-glucose environments by conserving pyrimidines and blocking apoptosis pathways. These adaptations minimize drug effectiveness by altering metabolism.

Researchers discovered that tumors grow uniformly throughout their mass, rather than faster at the edges. Using spatial genomics and computer simulations, the study analyzed mutation patterns in liver cancer.

Researchers mapped gene expression across the mouse intestine, revealing its stability and adaptability to changes like inflammation. The study identified immune-controlled regions and resilient spatial patterns.

A thymus atlas reveals that immune foundations are set as early as 12 weeks post-conception. Researchers uncovered key T cell development processes, offering insights for engineering immune cells to treat cancer and autoimmune diseases.

A study reveals that 3% of normal breast cells in healthy women have chromosomal abnormalities linked to invasive breast cancer, challenging current cancer detection methods. Aneuploid cells accumulate with age and mimic invasive cancer profiles.