The Immune System – News and Features
Anti-Sperm Antibody Contraceptive Tested in Phase 1 Clinical Trial
Researchers have developed an anti-sperm monoclonal antibody called the Human Contraception Antibody. The antibody was found to be safe and possess potent sperm agglutination and immobilization activity in laboratory tests and is now being testing in a Phase 1 Clinical trial.
New Developments in Multiplexing Aim To Reduce Immunoassay Variability
Immunoassays are used for a wide variety of proteomic and genomic applications in drug discovery and development. In this article, we discuss the advantages of multiplexing over single-plex methods and highlight key considerations when developing a multiplex assay.
Combating Infection With Smart Bandages
A team led by assistant professor Daniel Roxbury from the University of Rhode Island has developed a “smart bandage” – by combining bandage fibers with nanosensors – designed to detect wound infection by measuring levels of hydrogen peroxide.
Why Are Newborns So Susceptible to Bacterial Meningitis?
Scientists have demonstrated that the immaturity of both the gut microbiota and epithelial barriers play a role in the susceptibility of newborn infants to bacterial meningitis caused by Group B streptococcus.
Bacterial Enzyme Blueprint Helps Drug Designers Discover Ways To Fight Infection
Scientists have created the first fine-detail molecular blueprints of a bacterial enzyme called "Lit", which is suspected to play a key role in the progression of infection by dampening the immune response. This blueprint could help drug developers to design better therapeutic strategies to combat infection.
Study Investigates Liposome Accumulation in Tumors
A new study sheds light on the mechanism of liposome accumulation in tumors. The researchers say that the findings could impact how we diagnose, monitor and treat tumors with liposomes.
Overcoming the Challenges of Lentiviral Vector Production
In this interview, Dr. Koh Meng Yong discusses the advantages of using lentiviral vectors and some of the applications they are enabling.
Existing Drug Could Reduce the Risk of Kidney Cancer Returning
Research shows that using pembrolizumab at an earlier stage of kidney cancer could reduce the risk of cancer recurring by a third.
Stem Cells Can Use Same Method as Plants and Insects To Protect Against Viruses
Researchers at the Francis Crick Institute have found a vital mechanism, previously thought to have disappeared as mammals evolved, that helps protect mammalian stem cells from RNA viruses such as SARS-CoV-2 and Zika virus. The scientists suggest this could one day be exploited in the development of new antiviral treatments.
Bacterial Metabolites Can Boost the Effectiveness of Tumor Therapies
Scientists have demonstrated that bacterial metabolites can increase the cytotoxic activity of certain immune cells and thus positively influence the efficiency of tumor therapies.