The Immune System – News and Features

Researchers have identified a signaling loop involved in the growth and persistence of leukemia cells, and developed a novel immunotherapy that can disrupt that loop to boost immune function and improve survival.

Discover what glycan analysis can reveal about protein behavior and how it can be used to boost biologic performance and ensure therapeutic quality in biopharmaceutical drug development.

The study found a potential link between growth problems among infants and high levels of toxic metals and other elements in the breast milk of Mayan women in Guatemala’s Lake Atitlán watershed region.

Replacing mutated microglia with healthy microglia halts the progression of the genetic neurological disease adult-onset leukoencephalopathy with axonal spheroids and pigmented glia in mice and humans.

By analyzing just a drop of blood, a novel microchip system, known as microfluidic EM-based polyclonal epitope mapping, gives researchers quicker-than-ever insight into how a person’s antibodies are interacting with a virus or other pathogen.

Using detailed genetic analysis and manipulation, researchers show that continuous T-bet expression in these cells is key to preserving the protective memory response.

Researchers developed a nasal antibody that blocks mugwort pollen, a major hay fever trigger in Europe and Central Asia. Delivered intranasally, it reduced allergic symptoms and inflammation in mice without systemic side effects.

The results offer real-world data that support long-term protection through vaccination and suggest a level of population immunity.

Scientists have discovered novel drug candidates that could ultimately lead to new effective treatments for conditions caused by tissue stress and inflammation, including neuropathic pain and ischemia-reperfusion injury.

Women diagnosed with premenstrual symptoms have a slightly increased risk of developing cardiovascular disease later in life. This is shown by a new study from Karolinska Institutet published in Nature Cardiovascular Research.