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Vaccine Design and Testing – News and Features

COVID-19 Virus.

Novel Compound Protects Against COVID Virus in Preclinical Studies

Stapled lipopeptides successfully deter infection by the SARS-CoV-2 virus and reduce the severity of COVID-19 in tests with hamsters. Clinical trial now under way of compound's effectiveness as a nasal spray in humans.
Vaccine vials in production.

Why Do Vaccines Not Work Well in Some Older Adults?

Researchers at The Jackson Laboratory and UConn Health are rigorously investigating why vaccines don’t work as well in some older adults.
Illustration of gloved hands using scissors and tweezers to alter a DNA double helix.

Genetic Modification Techniques and Applications

Manipulating genetics has helped mankind in numerous ways. In this article, we consider genetic modification strategies, including genome editing and genetic engineering, the techniques used to achieve them and purposes to which they are applied.
A cell under fluorescent microscopy.

Unveiling Cellular Secrets, Researchers Show Location Is Everything

Messenger RNA (mRNA) is translated into proteins in the cytoplasm of cells. But rather than being a uniform “soup,” the cytoplasm is divided into multiple distinct compartments or regions.
A syringe and a vaccine vial on a blue background.

Nanoparticle-Based Flu Vaccine Shows Promise in Early Tests

A new nanoparticle-based vaccine could provide broad, rather than seasonal, protection against influenza A.
A child receives an injection from a clinician.

Most US Parents Plan To Vaccinate Their Children Against the “Tripledemic”

The first national study of its kind suggests that most US parents plan to vaccinate their children against influenza, COVID-19 and respiratory syncytial virus.
Colorized 3D prints of HIV virus particles.

Greater CD8+ T-Cell Activity May Increase HIV Immunity

An effective HIV vaccine may need to prompt strong responses from immune cells called CD8+ T cells to protect people from acquiring HIV, according to a new study from researchers at the National Institute of Allergy and Infectious Diseases (NIAID).
DNA double helix unravelling.

Synthetic DNA Advances Will Catalyze the Next Wave of Biotherapeutic Innovation

This article explores how biopharmaceutical organizations seeking to remain competitive must adopt innovations, like cell-free long DNA synthesis, to unleash the potential of synthetic biology and accelerate therapeutic development across all facets of genetic medicine.

A scientist pipettes liquid into a device attached to a laptop.

Compact DNA Sequencers Monitor Malaria Drug Resistance in Near Real-Time

Scientists have developed a technique to rapidly and reliably detect genetic changes in malaria parasites in Ghana, using just a gaming laptop and portable sequencer.
Blue influenza virions surrounded by a green membrane.

Studying the Evolutionary History of Flu Viruses Shapes Vaccine Development

Studying the evolutionary history of influenza viruses to quantitatively analyze how they evolved may help predict future strains and guide vaccine development.