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Selection of Label-free Cellular Imaging Applications for their Integration in the Screening Strategy
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Gerardo Turcatti, Ecole Polytechnique Federale De Lausanne, speaking at Screening Europe 2015.

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Fragment-based Approach to Multi-target Compounds
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The presented work deals with the development of a fragment based strategy for dual-target drug discovery.

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A Structured Approach to Academic Drug Discovery
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Simon Ward, University of Sussex, speaking at Discovery Chemistry Congress 2015

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Tissue and cfDNA Rare Alleles How Low Can We Go
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Seth Crosby, Washington University School of Medicine, discusses both bench and informatic methods used to increase specificity in the apprehension of rare cfDNA alleles.

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Fit-for-Purpose Biomarker Assay Validation - From Research Tool to Diagnostic Test
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Jeff Cummings presents a worked example of circulating tumour cell enumeration as a prognostic/predictive biomarker in cancer research.

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New Metabolomics Biomarker for Heart Failure
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Metabolomics has been successfully applied to identify and validate biomarkers for congestive heart failure. Diagnosis and risk stratification of heart failure (HF) is challenging.

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Continuous Flow Synthesis: Laboratory Approach & Protocol for Scale-up
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Amol Kulkarni, National Chemical Laboratory, speaking at Flow Chemistry India.

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Exploring Protein-protein Interactions Using Scaffolded and Assembled Peptides as Synthetic Binding Site Mimics
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Jutta Eichler, University of Erlangen-Nuremberg, speaking at Discovery Chemistry Congress 2015.

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Choosing & Using Fragments in the Generation of Selective Kinase Inhibitors
Video

There is often a debate about just how useful fragments are for well-established conventional targets such as protein kinases. Fragment screening however can be extremely valuable, providing critical ideas that lead to novelty, demonstrating how to achieve selectivity, helping dissect and make the most of HTS and literature compounds, alongside maximising ligand efficiency.

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Bioorthogonal Palladium-Labile Prodrugs for Site-Specific Anticancer Therapy
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Asier Unciti-Broceta, University of Edinburgh, speaking at Discovery Chemistry Congress 2015.

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