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Emerging Toxins in Food and Feed
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Despite huge research investments on mycotoxins and other toxic secondary metabolites of fungi and plants, prevention, control and proper exposure assessment remain difficult and agricultural and food industry continue to be vulnerable to problems of contamination.

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Current Pitfalls in Allergen Analysis
Video

DNA and/or protein based techniques are used for the analysis of food allergens. The advantages and disadvantages of each method need to be considered on a case-by-case basis and will be highlighted in the presentation.

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Advanced Targeting with Chimeric Antigen Receptors
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Martin Pule, Autolus Ltd discusses Advanced Targeting with Chimeric Antigen Receptors at Antibodies in Drug Discovery 2016.

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Bringing Biologically Relevant Cells to Life - iPSC Technology in Discovery and Safety Assessment
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AstraZeneca present data, showing large scale generation of functional pancreatic beta-cells, at a scale commensurate with drug-discovery activities. Furthermore, data is presented demonstrating the power of combining precise genome editing with iPSC technology in target validation.

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OptiLinked FDCs: Fully Armed Antibody Fragment Drug Conjugates
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Mahendra Deonarain, Antikor Biopharma Ltd, UK discusses Fully-Armed Antibody Fragment Drug Conjugates at Antibodies in Drug Discovery 2016.

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Decomposing the Sources of Molecular Variation in Human Induced Pluripotent Stem Cells
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Here, we describe the initial analysis of the genomes, epigenomes, transcriptomes and proteomes of IPS lines from healthy individuals generated by HIPSCI.

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Biomaterials as Stem Cell Regulators in the Development of in vitro Tissue Models
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An overview on the versatility of polyurethane chemistry and their role as stem cell regulators in the design of scaffolds for regenerative medicine or pharmaceutical, diagnostic investigation to test new therapeutic strategies/drugs or elucidate aspects of cell functionality.

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Discovery and Manufacturing Strategies for Novel, Homogeneous ADC Molecules
Video

Several key learnings have emerged through application of rapid re-iterative ADC design using reactive non-natural amino acids to specifically position conjugation sites: Site-specific homogeneous molecules can improve therapeutic index preclinically and have the potential to optimize clinical impact for a given combination of antibody and warhead. Site matters.

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High Content Analysis Of Human Pluripotent Stem Cell-Derived Endothelial Cells
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The goal of our project is to better identify and grow the optimal endothelial populations following their generation from human pluripotent stem cell cultures. The production of adequate cells is critical for the success of cell-based drug discovery in ischemic disease.

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Bi-specific Redirected T-cell Immunotherapy Targeting P-cadherin Expressing Tumors
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Lioudmila Tchistiakova, Senior Director, Pfizer Inc, USA, speaking at Antibodies in Drug Discovery.

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