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Imaging Biomarkers - Future or Reality
Video

Imaging has been at the heart of Medicine for many decades. However, its influence is changing as the need increases not only for diagnosis of disease, but also for quantification of disease extent, identification of suitable candidates for treatment and for testing of both treatment response or assessment of potential side effects for new treatments.

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High-Throughput Approaches to Cell Biology
Video

Robin Ketteler, University College London, discusses high throughput screening of autophagy using siRNA and small molecule compounds.

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Discovery of Potent and Selective Inhibitors of Monopolar Spindle 1 (MPS1) Kinase
Video

This talk presents the discovery and optimization of potent and selective MPS1 inhibitors based on the 1H-pyrrolo[3,2-c]pyridine scaffold, guided by structure-based design and cellular characterization of MPS1 inhibition.

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Genome-Scale Protein Expression Analysis of Individual Solid Tumors
Video

Present diagnostic procedures and therapeutic strategies solid tumours rely on the detection and targeting of specific marker molecules to classify the tumour and to design an efficient therapy.

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Selection of Label-free Cellular Imaging Applications for their Integration in the Screening Strategy
Video

Gerardo Turcatti, Ecole Polytechnique Federale De Lausanne, speaking at Screening Europe 2015.

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Fragment-based Approach to Multi-target Compounds
Video

The presented work deals with the development of a fragment based strategy for dual-target drug discovery.

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A Structured Approach to Academic Drug Discovery
Video

Simon Ward, University of Sussex, speaking at Discovery Chemistry Congress 2015

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Tissue and cfDNA Rare Alleles How Low Can We Go
Video

Seth Crosby, Washington University School of Medicine, discusses both bench and informatic methods used to increase specificity in the apprehension of rare cfDNA alleles.

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Fit-for-Purpose Biomarker Assay Validation - From Research Tool to Diagnostic Test
Video

Jeff Cummings presents a worked example of circulating tumour cell enumeration as a prognostic/predictive biomarker in cancer research.

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New Metabolomics Biomarker for Heart Failure
Video

Metabolomics has been successfully applied to identify and validate biomarkers for congestive heart failure. Diagnosis and risk stratification of heart failure (HF) is challenging.

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