Insights into Evaporative Light Scattering Detection (ELSD) in Chromatography
Evaporative Light Scattering Detection (ELSD) is one type of detection methods used in flash chromatography and prep HPLC. Briefly, the mechanism of ELSD involves measuring the amount of light scattered by particles of solvent, which have been dried through evaporation.
Adaptive Sampling: Target Regions of DNA in Real Time
It’s possible to target regions of DNA in real time using adaptive sampling on nanopore devices. The nanopore has the ability to read the strand sequence in real time, if it is not the strand of interest, the strand is ejected, but if it is, the nanopore recognises this and continues to read the strand. Researchers then get more of the sequence they are interested in within a shorter period of time, allowing faster and easier analysis.
Modelling A Chronic Pain Condition In A Dish
Erythromelalgia is a chronic pain condition causing burning pain sensation and reddening. We discuss how to model the phenotype and pharmacological response using iPSC technology and directed differentiation.
Modular Human Biochip-based Organoid Models in Biomedical Research
A novel biochip organoid platform involving circulating primary immune cells has been developed for the investigation of sepsis-related organ dysfunction. Organoid models are capable to mimic inflammation-related organ failure as well as essential aspects of of tissue repair.
The Patent Landscape of Organs-on-a-Chip
The presentation will focus on ways to protect organs-on-a-chip innovation, patent filings directed to organs-on-a-chip technology, certain exceptions to patent infringement, as well as the possibility of future litigation.
The Commercialisation of Organs-on-Chips Case Study
In this presentation I will discuss the development and commercialisation of CN Bio Innovation’s LiverChip platform together with Quantum B our full viral life cycle model of Hepatitis B infection and look ahead to opportunities for multi-organ systems.
Commercial Development of Organ-on-a-chip Systems – Challenges and Strategies
Juliane Schnabel, Microfluidic ChipShop GmbH, Germany, speaking at Organ-on-a-Chip Europe 2016.
Hierarchically Structured Biomaterials for Bone-on-a-Chip Devices and Bone Tissue Engineering
Frederik Claeyssens, Senior Lecturer, Materials Science and Engineering, University of Sheffield, speaking at Organ-on-a-Chip Europe 2016.
Microfluidic Chips and Cancer Treatment
The interdisciplinary lab on a chip group at the University of Hull have been characterizing and optimizing devices that can maintain fresh tissue biopsies in a functional state. This tissue can then be subjected to various “treatments” and the effects measured through analysis of the supernatant or post-treatment tissue. Results from varied tumour types and analyses will be presented.
A Microfluidic Chip based Model for the Study of Full Thickness Human Intestinal Tissue
A dual-flow microfluidic device has been optimised to hold human gut biopsies in a known orientation mimicking the biomimetic environment, with continual media perfusion and simultaneous waste removal. Characterisation of the tissue by measuring cell death, proliferation, histology and soluble inflammatory biomarkers has shown that it remains viable and functional.
Kidney on a Chip using Cell Sheet Engineering
There is a need for an improved kidney-on-a-chip for applications in toxicity testing and early stage compound screening. The filtration structures in a kidney are thin cell sheets that act as membranes. Here we present a cell sheet concept for a more accurate representation of a kidney for in vitro organ models.
Cancer Extravasation Dynamics in an In Vitro Blood Vessel Model
The aim of this research is to investigate breast cancer extravasation in vitro, using a microfluidic system mimicking the 3D in vivo vascular microenvironment. This microfluidic platform can be used to quantify cancer cell morphological changes during the invasion process.