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OptiLinked FDCs: Fully Armed Antibody Fragment Drug Conjugates
Mahendra Deonarain, Antikor Biopharma Ltd, UK discusses Fully-Armed Antibody Fragment Drug Conjugates at Antibodies in Drug Discovery 2016.
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Decomposing the Sources of Molecular Variation in Human Induced Pluripotent Stem Cells
Here, we describe the initial analysis of the genomes, epigenomes, transcriptomes and proteomes of IPS lines from healthy individuals generated by HIPSCI.
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Biomaterials as Stem Cell Regulators in the Development of in vitro Tissue Models
An overview on the versatility of polyurethane chemistry and their role as stem cell regulators in the design of scaffolds for regenerative medicine or pharmaceutical, diagnostic investigation to test new therapeutic strategies/drugs or elucidate aspects of cell functionality.
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Discovery and Manufacturing Strategies for Novel, Homogeneous ADC Molecules
Several key learnings have emerged through application of rapid re-iterative ADC design using reactive non-natural amino acids to specifically position conjugation sites: Site-specific homogeneous molecules can improve therapeutic index preclinically and have the potential to optimize clinical impact for a given combination of antibody and warhead. Site matters.
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High Content Analysis Of Human Pluripotent Stem Cell-Derived Endothelial Cells
The goal of our project is to better identify and grow the optimal endothelial populations following their generation from human pluripotent stem cell cultures. The production of adequate cells is critical for the success of cell-based drug discovery in ischemic disease.
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Bi-specific Redirected T-cell Immunotherapy Targeting P-cadherin Expressing Tumors
Lioudmila Tchistiakova, Senior Director, Pfizer Inc, USA, speaking at Antibodies in Drug Discovery.
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Single Domain Antibodies: From Conformational Sensors to Bispecific Antibodies for Immunotherapy
We are using single domain antibodies as innovative tools such as biosensors able to capture the conformation states of some membrane receptors such as EGFR or metabotropic glutamate receptors (mGluRs) on living cells.
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Integration of High Throughput ‘Omic Platforms into Antibody Discovery
In pursuit of lead structures, ‘omic technologies are revolutionizing the discovery and development of novel biological lead structures.
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Targeting ION Channels with Biologics
We will describe a novel approach to target such ion channels with antibody-based drugs and present a case study where functional channel-closing and modulating antibodies have been successfully identified to a ligand-gated ion channel.
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Complex Tissue Models that Mimic the Tumour Microenvironment, Heterogeneity and Invasion of Cancer
Matthias Nees, University of Turku, Finland, speaking at High Content & Phenotypic Screening 2016.
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