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Utilizing hiPSC-Derived Neurons and Cardiomyocytes For Drug Screening
Patient-specific primary cells and human induced pluripotent stem cells (hiPSC) complement traditional cell-based drug discovery assays and could aid in the development of clinically useful compounds. We will discuss our high content screening results and development of patient specific hiPSC based models for drug discovery.
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3D Human Pluripotent Stem Cell-Derived Heart-In-A-Jar
This presentation will give an overview of the platform of tools that we have been developing, validating and characterising to look at cardiac maturation drug discovery.
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Modelling A Chronic Pain Condition In A Dish
Erythromelalgia is a chronic pain condition causing burning pain sensation and reddening. We discuss how to model the phenotype and pharmacological response using iPSC technology and directed differentiation.
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Modular Human Biochip-based Organoid Models in Biomedical Research
A novel biochip organoid platform involving circulating primary immune cells has been developed for the investigation of sepsis-related organ dysfunction. Organoid models are capable to mimic inflammation-related organ failure as well as essential aspects of of tissue repair.
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The Patent Landscape of Organs-on-a-Chip
The presentation will focus on ways to protect organs-on-a-chip innovation, patent filings directed to organs-on-a-chip technology, certain exceptions to patent infringement, as well as the possibility of future litigation.
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The Commercialisation of Organs-on-Chips Case Study
In this presentation I will discuss the development and commercialisation of CN Bio Innovation’s LiverChip platform together with Quantum B our full viral life cycle model of Hepatitis B infection and look ahead to opportunities for multi-organ systems.
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Commercial Development of Organ-on-a-chip Systems – Challenges and Strategies
Juliane Schnabel, Microfluidic ChipShop GmbH, Germany, speaking at Organ-on-a-Chip Europe 2016.
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Hierarchically Structured Biomaterials for Bone-on-a-Chip Devices and Bone Tissue Engineering
Frederik Claeyssens, Senior Lecturer, Materials Science and Engineering, University of Sheffield, speaking at Organ-on-a-Chip Europe 2016.
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Microfluidic Chips and Cancer Treatment
The interdisciplinary lab on a chip group at the University of Hull have been characterizing and optimizing devices that can maintain fresh tissue biopsies in a functional state. This tissue can then be subjected to various “treatments” and the effects measured through analysis of the supernatant or post-treatment tissue. Results from varied tumour types and analyses will be presented.
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A Microfluidic Chip based Model for the Study of Full Thickness Human Intestinal Tissue
A dual-flow microfluidic device has been optimised to hold human gut biopsies in a known orientation mimicking the biomimetic environment, with continual media perfusion and simultaneous waste removal. Characterisation of the tissue by measuring cell death, proliferation, histology and soluble inflammatory biomarkers has shown that it remains viable and functional.
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