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Exploring Protein-protein Interactions Using Scaffolded and Assembled Peptides as Synthetic Binding Site Mimics
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Jutta Eichler, University of Erlangen-Nuremberg, speaking at Discovery Chemistry Congress 2015.

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Choosing & Using Fragments in the Generation of Selective Kinase Inhibitors
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There is often a debate about just how useful fragments are for well-established conventional targets such as protein kinases. Fragment screening however can be extremely valuable, providing critical ideas that lead to novelty, demonstrating how to achieve selectivity, helping dissect and make the most of HTS and literature compounds, alongside maximising ligand efficiency.

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Bioorthogonal Palladium-Labile Prodrugs for Site-Specific Anticancer Therapy
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Asier Unciti-Broceta, University of Edinburgh, speaking at Discovery Chemistry Congress 2015.

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Creating a Clinical Diagnostic Test from Discovery Through Launch with Mass Spectrometry
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Targeted mass spectrometry, called MRM or SRM, allows for the rapid quantification of hundreds of proteins in a single assay. This tool is very specific, highly quantitative and requires very little sample (e.g. < 5 uL plasma).

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LC-High Resolution-MS in Clinical Labs: A Step Forward for TDM and Metabotyping
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Research/routine and quantitative/qualitative analyses using LC-HR-MS will be presented for drug and peptide determinations in patients’ plasma.

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Capturing D Genome Variation for Wheat Improvement
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The diploid D genome species, Aegilops tauschii Coss. is source of allelic variation for hexaploid wheat, Triticum aestivum L and has provided numerous genes for resistance to diseases and insect pests.

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Biomarkers to Predict Aggressive Prostate Cancer
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Claire Morgan discusses the need to identify a panel of biomarkers that may distinguish indolent cancer from aggressive metastatic disease when used collectively.

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Contributions of Mass Spectrometry in the Diagnosis and Management of Hypothalamic–pituitary–adrenal Axis Disorders
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Mass spectrometry is increasingly used in clinical laboratories for the measurement of steroid hormones. In fact, clinical biochemistry and endocrine societies emphasize in their documents the enhanced analytical specificity for mass spectrometry measurements of steroids in comparison with conventional immunoassays.

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Characterising Plant Genomes The Good The Bad and The Ugly
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Next generation DNA sequencing has revolutionised biology. However, the low cost and relative ease in generating draft genome assemblies has led to the production of many genome sequences of questionable quality or applicability.

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