Beyond Five Bases: See What Your Data’s Missing
Genetics alone doesn’t tell the full story – dynamic regulatory layers determine how genetic information is expressed. Genomic approaches miss these critical signals, leaving gaps in our ability to predict cellular changes.
In this Teach Me in 10, Dr. Donna McDade Walker, Vice President of Global Marketing, Product Management and Communications at biomodal, will explore the 6 base genome – where epigenetic modifications such as 5 methylcytosine (5mC) and 5 hydroxymethylcytosine (5hmC) reveal a cell’s dynamic state and early signals of change, helping you predict the future of cellular behavior and disease progression.
Watch this episode to understand how:
- Standard approaches overlook methylation state changes and gene regulation
- 5hmC and 5mC patterns inform cell activation and identity, and their significance for detection
- The duet multiomics solution evoC delivers 6 base data with unrivaled sensitivity and specificity in a single workflow
Further Resources:
Article – 5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer
Publication – Temporally discordant chromatin accessibility and DNA demethylation define short- and long-term enhancer regulation during cell fate specification
Scientific Poster – Inferring gene regulation from 6-base sequencing data in multiple tissues
Scientific poster – Inferring genome organisation and gene regulation from 6-base sequencing data
Product Sheet – Duet multiomics solution evoC
6-base sequencing analysis software – modality XPLR
