The proteome is the most functional component encoded for in the genome. Advances in proteomic technologies allow comprehensive profiling of of signaling pathways, precise expression of therapeutic targets in tissues and cellular subcompartments, and of metabolomic features that determine likelihood of therapeutic response. Moreover the current paradigm shift in cancer therapy with dramatic and durable responses to antibody and checkpoint therapeutics that trascend tumor genomic profiles further emphasize opportunities to identify novel targets and tailor treatment based on their expression patterns. The potential for personalizing cancer treatment based on proteomic and metabolomic profiles will be presented for epithelial type tumors including lung and pancreatic cancer.
Beyond Genomics For Personalized Medicine
Video Sep 19, 2016
Professor Sir Doug Turnbull from the Wellcome Trust Centre for Mitochondrial Research at the University of Newcastle explains his research into mitochondrial donation, the innovative treatment that hopes to stop faulty mitochondria being passed on from mother to child to prevent incurable genetic diseases.
The first babies conceived with this treatment through IVF may be born in the UK soon.
From their diet to their diseases, koalas are pretty special. Now researchers have sequenced the koala’s genome, unlocking the secrets that make these fuzzy fellas so unique. The genome is revealing everything from how koalas cope with munching poisonous eucalyptus leaves, to how they respond to chlamydia infections. The hope is that these insights will not only help us understand these fascinating marsupials, but also aid conservation efforts across Australia.