We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Complex Tissue Models that Mimic the Tumour Microenvironment, Heterogeneity and Invasion of Cancer

Video   Jan 03, 2017

 

The main goal is the development of cell culture model systems to recapitulate key aspects of cancer progression and to functionally validate biomarkers, target genes, and molecular signaling pathways. HCSLab develops complex, organotypic cell-and tissue culture models specifically for phenotypic high content screening, in the areas of both oncology and neuronal diseases. The tumour models aim towards the faithful recapitulation of the complex histology of tumours, including the role of the tumour microenvironment, and monitoring of dynamic cellular processes such as tumour/stroma interactions, tumor cell plasticity, differentiation versus de-differentiation, and tumour cell invasiveness. We recreate living tumour microtissues in vitro for real-time, live cell monitoring of disease processes. The development of complex 3D co-culture models is combined with thorough standardization and miniaturization of the assays, and assisted by automated image analysis software to allow real-time, live cell screening. We will further demonstrate the use of statistical and mathematical algorithms to quantitatively assess the most relevant and significant morphometric changes in tissue architecture upon drug exposure and genetic modifications.

 
 
 
 

Recommended Videos

The Top 5 Strangest Poisons That Can Kill You

Video

There are some crazy poisons in this world of ours, and they’re often found in things you’d least expect. Here we break down the top five.

WATCH NOW

Sanger Institute - UK Biobank Whole Genome Sequencing Project

Video

The genetic code of all 500,000 UK Biobank volunteer participants will be sequenced by researchers at the Wellcome Sanger Institute in the UK and deCODE genetics in Iceland. This project is the single most ambitious sequencing programme in the world undertaken by a public-private partnership, and will power the next wave of genetic and health research

WATCH NOW

Designing Microbiome Therapeutics to Help Cure Cancer

Video

A healthy microbiome increases the efficacy of drugs such as checkpoint inhibitors which take the blindfold off of the immune system, allowing it to recognize, attack, and kill cancer cells. Unfortunately, 70% of cancer patients don’t respond to this drug treatment due to severely damaged microbiomes which have limited kinds of bacteria.

WATCH NOW

 

Like what you just watched? You can find similar content on the communities below.

Analysis & Separations Cancer Research Cell Science Drug Discovery Genomics Research

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE