We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Advertisement

Complex Tissue Models that Mimic the Tumour Microenvironment, Heterogeneity and Invasion of Cancer

Video   Jan 03, 2017

 

The main goal is the development of cell culture model systems to recapitulate key aspects of cancer progression and to functionally validate biomarkers, target genes, and molecular signaling pathways. HCSLab develops complex, organotypic cell-and tissue culture models specifically for phenotypic high content screening, in the areas of both oncology and neuronal diseases. The tumour models aim towards the faithful recapitulation of the complex histology of tumours, including the role of the tumour microenvironment, and monitoring of dynamic cellular processes such as tumour/stroma interactions, tumor cell plasticity, differentiation versus de-differentiation, and tumour cell invasiveness. We recreate living tumour microtissues in vitro for real-time, live cell monitoring of disease processes. The development of complex 3D co-culture models is combined with thorough standardization and miniaturization of the assays, and assisted by automated image analysis software to allow real-time, live cell screening. We will further demonstrate the use of statistical and mathematical algorithms to quantitatively assess the most relevant and significant morphometric changes in tissue architecture upon drug exposure and genetic modifications.

 
 
 
Advertisement
 

Recommended Videos

The Many Faces of the Thermo Scientific Vanquish Duo UHPLC System for Increased Productivity in Biopharma Analyses

Video

The Thermo Scientific Vanquish Duo UHPLC System can give analytical scientists a productivity boost for the many different analyses needs they might have to ensure fast and well-informed drug development.

WATCH NOW

Teach Me in 10 – Microbial Epigenomics With Dr Pedro Oliveira

Video

In this instalment of Teach Me in 10, we're joined by Dr Pedro Oliveira, Senior Scientist at Mount Sinai School of Medicine, whose scientific interests center on the bioinformatics, comparative genomics and epigenomics of bacteria, particularly the interplay between methylation, gene flux and chromosome organization.

WATCH NOW

Teach Me in 10 - CRISPR, Cell Therapies and Drug Discovery With Dr Theo Roth

Video

This instalment of Teach Me in 10 features Dr Theo Roth, whose work bridges a number of different fields, such as genome engineering, cancer immunology and cell-based therapies.

WATCH NOW

 

Like what you just watched? You can find similar content on the communities below.

Analysis & Separations Cancer Research Cell Science Drug Discovery Genomics Research

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE