Recently, we evaluated the performance of 190 candidate protein biomarkers to discriminate between patients with benign or malignant lung nodules. The candidate markers came from the substantial literature on cancer-associated proteins as well as from mass spectrometry studies, conducted in-house to identify proteins up-regulated either on the surface of tumors or in the secretome of tumors, as compared to adjacent normal lung tissue. Plasma samples were obtained retrospectively for analysis from those with either benign or malignant nodules. A 13 protein panel was identified with a high negative predictive value, able to remove approximately half of those with benign nodules from further consideration. The test has been commercialized, using MRM mass spectrometry, by Integrated Diagnostics.
Creating a Clinical Diagnostic Test from Discovery Through Launch with Mass Spectrometry
Video Apr 14, 2015
When healthy people eat a low-gluten and fibre-rich diet compared with a high-gluten diet they experience less intestinal discomfort including less bloating, a new study shows. The researchers attribute the impact of diet on healthy adults more to change in composition of dietary fibres than gluten itself.WATCH NOW
World Congress on Recent Advances in Aquaculture Research & Fisheries
Jun 10 - Jun 11, 2019