Recently, we evaluated the performance of 190 candidate protein biomarkers to discriminate between patients with benign or malignant lung nodules. The candidate markers came from the substantial literature on cancer-associated proteins as well as from mass spectrometry studies, conducted in-house to identify proteins up-regulated either on the surface of tumors or in the secretome of tumors, as compared to adjacent normal lung tissue. Plasma samples were obtained retrospectively for analysis from those with either benign or malignant nodules. A 13 protein panel was identified with a high negative predictive value, able to remove approximately half of those with benign nodules from further consideration. The test has been commercialized, using MRM mass spectrometry, by Integrated Diagnostics.
Creating a Clinical Diagnostic Test from Discovery Through Launch with Mass Spectrometry
Video Apr 14, 2015
Our Behind the Science host Jen goes back to our new 2D-LC lab to meet Claude Mallet, Ph.D., a senior scientist at Waters, and Sabra Botch-Jones, M.S., M.A., D-ABFT-FT, an assistant professor in the department of Anatomy & Neurobiology, Biomedical Forensic Sciences, at Boston University School of Medicine (http://www.bumc.bu.edu/gms/msci/about...) to learn how her lab uses 2DLC.WATCH NOW
8th Edition of International Conference and Exhibition on Separation Techniques
Jul 29 - Jul 30, 2019