Expanding Possibilities for Compound Library Generation in Flow with Immobilized and Exchangeable Reagents

About the Speaker
Noah Tu is a Senior Scientist with Discovery Chemistry and Technology at AbbVie Inc in North Chicago, Illinois. Noah has over 20 years of experience in the pharmaceutical industry. He joined Abbott Laboratories as a medicinal chemist in 1994 after graduating from University of Victoria in Canada. In 2000 Noah established the High Throughput Organic Synthesis group in Abbott Laboratories for compound library synthesis. In 2002 Noah joined S*BIO, a startup company in Singapore, and established the High Throughput Synthesis and Analytic group. Noah rejoined Abbott/AbbVie in 2006 and has pioneered in the setup of several novel integrated synthesis-purification systems for rapid compound library generation.
AbstractA custom-built modular flow reactor featuring immobilized reagents in exchangeable cartridges has been developed. The concept is based on a custom designed flow reactor with easy access to internal components for reagent cartridge exchange. Custom made reagent cartridges filled with different supported catalysts and reagents are used for various reaction conditions. The custom reactor has, as one component, the same footprint as the Accendo ConjureTM reactor and no hardware or software modification to the Conjure unit is required. This reactor opens the way to chemical transformations previously not readily achievable with Accendo Conjure flow chemistry system. In this presentation, we demonstrate the applicability of this system to tandem Click-Suzuki reactions.