We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Fragment-based Approach to Multi-target Compounds

Video   May 08, 2015

 

Here, we applied a modified self-organizing map algorithm for in silico recognition of molecular fragments binding two targets: 5-lipoxygenase and soluble epoxide hydrolase. The predicted properties were confirmed by complementary screening techniques: STD-NMR and enzyme assay. A variety of dual fragments active in both complementary assays could be obtained using self-organizing maps, which was optimized towards nanomolar inhibitory activity against both targets.

 
 
 
 

Recommended Videos

Introduction to Dynamic Light Scattering Analysis

Video

Dynamic Light Scattering (DLS) is a technique classically used for measuring the size of particles typically in the sub-micron region, dispersed in a liquid. The sensitivity of some modern systems is such that it can also now be used to measure the size of macromolecules in solution.

WATCH NOW

Space Mirrors and Other Weird Ways To Fight Climate Change

Video

There are things you can do right now to help our climate--like investing in renewable energy. But today on Reactions, we're digging into a few of the weirdest climate change-combating ideas out there.

WATCH NOW

The Top 5 Strangest Poisons That Can Kill You

Video

There are some crazy poisons in this world of ours, and they’re often found in things you’d least expect. Here we break down the top five.

WATCH NOW

 

Like what you just watched? You can find similar content on the communities below.

Analysis & Separations Drug Discovery Informatics

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE