We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Fragment-based Approach to Multi-target Compounds

Video   May 08, 2015

 

Here, we applied a modified self-organizing map algorithm for in silico recognition of molecular fragments binding two targets: 5-lipoxygenase and soluble epoxide hydrolase. The predicted properties were confirmed by complementary screening techniques: STD-NMR and enzyme assay. A variety of dual fragments active in both complementary assays could be obtained using self-organizing maps, which was optimized towards nanomolar inhibitory activity against both targets.

 
 
 
 

Recommended Videos

Louis C. Herring Lab talks about their recent Aeris XRD addition

Video

X-ray diffraction (XRD) is an important tool in the analysis and identification of phases present in kidney stones. Louis C. Herring owner Glenn Austin discusses how well the Aeris fits with their workflow.

WATCH NOW

Investigating the World's Lightest Solid

Video

Aerogels are the world's lightest (least dense) solids. They are also excellent thermal insulators and have been used in numerous Mars missions and the Stardust comet particle-return mission. The focus of this video is silica aerogels, though graphene aerogels are now technically the lightest.

WATCH NOW

Introduction to MADLS: Multi-Angle Dynamic Light Scattering

Video

This video provides a simple introduction to the technique of MADLS – Multi-Angle Dynamic Light Scattering – exclusively available in Malvern Panalytical’s new Zetasizer Ultra.

WATCH NOW

 

Like what you just watched? You can find similar content on the communities below.

Analysis & Separations Drug Discovery Informatics

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE