We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Fragment-based Approach to Multi-target Compounds

Video   May 08, 2015

 

Here, we applied a modified self-organizing map algorithm for in silico recognition of molecular fragments binding two targets: 5-lipoxygenase and soluble epoxide hydrolase. The predicted properties were confirmed by complementary screening techniques: STD-NMR and enzyme assay. A variety of dual fragments active in both complementary assays could be obtained using self-organizing maps, which was optimized towards nanomolar inhibitory activity against both targets.

 
 
 
 

Recommended Videos

Operetta CLS High-Content Analysis System

Video

The Operetta CLS system is part of PerkinElmer's comprehensive HCS portfolio – from HCS systems and microplates to automation and informatics.

WATCH NOW

A revolution in the world of X-Ray Diffraction

Video

With the 3rd generation Empyrean, Malvern Panalytical has now redefined the concept of a multipurpose diffractometer: the newly designed MultiCore Optics enable the largest variety of measurements without any manual intervention.

WATCH NOW

In Pursuit of a Universal Antivenom

Video

When it comes to venomous snake bites, time is of the essence.
Find out how researchers are working to find an effective and affordable universal antivenom.

WATCH NOW

 

Like what you just watched? You can find similar content on the communities below.

Analysis & Separations Drug Discovery Informatics

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE