We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

From Sequencing to Interpretation: Bioinformatics Challenges in Next Generation Sequencing Cancer Dx

Video   Oct 06, 2016

 

Next generation sequencing (NGS) technologies are rapidly transforming clinical oncology diagnostics, allowing for dramatically expanded surveillance of nucleic acid signatures to support personalized prognostics and therapeutic interventions. New assay types and clinical targets continue to emerge, as does the associated data volume and complexity, creating unique and exciting challenges for those tasked with managing, analyzing and interpreting the resulting data. These challenges can be of a technical nature, as cancer specimens can be vanishingly small, with degraded nucleic acids, tumor cell heterogeneity and tumor/normal admixture, all of which are likely to produce signal-to-noise problems at the data level. They may also be of a holistic nature. High quality clinical NGS bioinformatics requires teamwork and interconnectedness, not only being responsive to laboratory and clinician needs but also helping to guide and inform laboratory practices, clinical interpretations as well as the overall mission. This lecture will use our experiences at The University of Chicago Medicine to highlight some of the common analytical, technical, and regulatory challenges that bioinformatics groups face when helping to set up oncology genomics clinical diagnostics practices.

 
Company Information
 
 
 

Recommended Videos

Invitrogen™ Collibri™ NGS Library Preparation Kits for Illumina™ Systems

Video

Watch the benefits of visual feedback at each step in the protocol. The colored dyes indicate proper addition and mixing of reagents with the Invitrogen Collibri DNA library preparation kits for Illumina systems.

WATCH NOW

Genes in the Enivornment

Video

Under the influence of longer-term climate change, crop growing conditions are becoming more extreme.

WATCH NOW

A Cancer Campaign for the Lads| Rugby Star Raises Awareness

Video

Former Welsh rugby captain and testicular cancer survivor Matthew Rees urges men to "check their tackle."

WATCH NOW

 

Like what you just watched? You can find similar content on the communities below.

Diagnostics Genomics Research Informatics

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE