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Generating Highly Multiplexed Immunofluorescence Data and Bridging the Gap Between Research and Conventional Clinical Pathology

To simultaneously visualize multiple markers within the same sample enables a more detailed view of cellular phenotypes and how they orient in space. This in turn brings deeper understanding of the function and interplay of different cell types in situ, of value for research related to many biological conditions. For most labs, accessing and applying emerging spatial methods for highly multiplexed detection of various types of molecules is not straight forward. The Spatial and Single Cell Biology (SSCB) platform at SciLifeLab offers several spatial omics methods as a service, including advanced single cell sequencing, spatial transcriptomics, in situ sequencing, spatial mass spectrometry and spatial proteomics. In this talk, Dr Stadler will present the possibilities for spatial omics as a service at SciLifeLab, with emphasis on the methods offered for spatial proteomics using highly multiplexed immunofluorescence. Further, she will discuss the opportunities and challenges for implementing multiplexed imaging into clinical practice, and she will give an example of how multiplexed imaging was used to diagnose lung cancer biopsies using a panel of 7 markers.