High-Throughput and High-Content Screening in Organoids and 3D Models With Michiel Fokkelman
In this Teach Me In 10 episode we are joined by Michiel Fokkelman, head of high throughput screening at Crown Bioscience.
We will discuss the concept and definitions of high content imaging, both for 2D and 3D cell culture systems. These rich and extensive morphological readouts provide phenotypic data showing the cellular response(s) to a compound or new potential drug. Michiel then explores the use of 3D-cultured organoids and how these are utilized in drug discovery and pre-clinical drug development using high content approaches. Finally, we will then look at the role of lab automation, essential in enabling high throughput and HCI-based phenotypic screening, and how you can benefit from these technologies.
Want to learn more? Michiel suggests looking at the following resources:
- Using High Content Screening in 3D Organoids
- Recent publication by Herpers et al
- Learn more about Organoids
- The added value of High Content Imaging
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