An innovative approach towards a marketable lab-on-a-chip system for in vitro diagnostics at the point-of-care is reported. A lab-on-a-chip system called the "Fraunhofer ivD-platform" has been established which opens up the possibility for an on-site analysis at low costs. The system features a high degree of modularity and integration. Modularity allows the adaption of common and established assay types of various formats. Integration lets the system move from the laboratory to the point-of-need. By making use of the microarray format the lab-on-a-chip system also addresses the trend of multiplex detection in biomedicine. The system consists of a credit-card sized cartridge (lab-on-a-chip) and a base-unit. A clinical sample, e.g. a drop of blood can be applied directly to the cartridge and will be analyzed automatically. All biochemical reagents, which are necessary for the assay, are already included in the cartridge. A proprietary pumping system enables an automated processing after insertion of the cartridge into the base-unit. After about 15 min, the results of the diagnostic analysis appear on a display and the physician can directly undertake therapeutic action. The open/flexible character of the ivD-platform, allows the integration of e.g. the following assay formats: - Immunological assays, automated ELISA (antibody - microarray)e.g. CRP-assay- Serological assays (protein / peptide - microarray)e.g. autoimmune-diagnostics- DNA diagnostics (DNA - microarray)e.g. species-identification + antibiotic resistance detection. Other assay formats are possible (e.g. using aptamers), but have not been tested so far. New or existing assays can easily be transferred onto the ivD-platform, which are then ready for mass production.
Highly-integrated Lab-on-a-chip System for Multiparameter Analysis at the Point-of-care
Video Jun 10, 2015
Meet the biohacker who wants to teach everyone how to edit genes.
Josiah Zayner is a biohacker who thinks everyone should be able to change their DNA with biotechnology called CRISPR. That’s why he founded a company called The ODIN, which sells do-it-yourself biotech kits that teach people how to genetically modify bacteria and frogs. It's DIY gene therapy.
His company has sold tens of thousands of experiments using CRISPR, an inexpensive and precise gene-editing technology that has revolutionized the field.
Science really is everywhere! From the Big Bang to quantum mechanics to free will to ice skating, we explore it all featuring Neil deGrasse Tyson, Chuck Nice, theoretical physicist Brian Greene, neuroscientist Heather Berlin, rapper Baba Brinkman, and Olympic silver medalist figure skater Sasha Cohen.WATCH NOW