Implementing Life Science Automation

A Mass. General Hospital study reveals how solid stress from nodular brain tumors compresses adjacent healthy tissue, restricts blood supply and damages neurons. The psychiatric drug lithium may be able to reduce these effects. (Giorgio Seano, PhD, Steele Laboratories of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital)

Following on from their groundbreaking 3D printed corneas, a team of researchers at Newcastle University have developed a technique to create self-forming corneas. The team now intend to take the work forward to refine the technique to produce corneas for human implant.

Key concepts discussed in this webinar will include: - Description of the in vitro test systems used to evaluate P-gp and - BCRP inhibition at Sekisui XenoTech and the advantages/disadvantages of these assays - Description of the test system qualification process that takes places prior to offering these assays in definitive studies - Comparison of IC50 values obtained from the different test systems - Comparison of IC50 and Ki values determined with the vesicle test system - How IC50 and Ki values are used to evaluate clinical relevance