We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Kidney on a Chip using Cell Sheet Engineering

Video   Oct 18, 2016

 

The current state-of-the-art for kidney toxicity testing requires extensive use of animal models to satisfy regulatory requirements. There is an increasing need for alternative methods of toxicity screening for pharmaceutical products led by economic, ethical and academic factors. At present cell culture based assays provide an inadequate method for toxicity screening and there is considerable interest in improving this to provide a better tool for early stage screening in the drug development cycle. Current organ-on-a-chip concepts for kidney studies are essentially miniaturised cell culture assays confined to a single cell type grown on a porous substrate. This does not adequately model the appropriate anatomy of the filtration components of the kidney. In order to improve on these designs we need to develop co-culture cellular models that better represent the kidney in vitro. Here we present preliminary work on a novel kidney on a chip concept using cell sheet engineering to address the challenge of producing an organ-on-a-chip model of the kidney glomerulus.

 
 
 
 

Recommended Videos

Understanding P-gp and BCRP Inhibition Assay Design and Outcomes

Video

Key concepts discussed in this webinar will include: - Description of the in vitro test systems used to evaluate P-gp and - BCRP inhibition at Sekisui XenoTech and the advantages/disadvantages of these assays - Description of the test system qualification process that takes places prior to offering these assays in definitive studies - Comparison of IC50 values obtained from the different test systems - Comparison of IC50 and Ki values determined with the vesicle test system - How IC50 and Ki values are used to evaluate clinical relevance

WATCH NOW

Watch Vaccinia Smallpox Infect a Cell

Video

This video shows the movement of cells infected with vaccinia smallpox.

WATCH NOW

Top Science Stories of 2018

Video

We have seen some amazing scientific breakthroughs in 2018. Here is a selection of our favorites.

WATCH NOW

 

Like what you just watched? You can find similar content on the communities below.

Cell Science Drug Discovery

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE