Loss-of-Function Genetic Screens with RNAi and CRISPR Libraries

In part two of their ICP-MS Teach Me in 10, Abe Gutierrez and Ed McCurdy help to answer the question: Why do we need triple quadrupole ICP-MS?

It may seem that rabbits that walk with their hind legs over their head--like an acrobat walking on her hands--belong in a circus, but this breed spends almost all the time in a lab. By comparing these sauteur d’Alfort with run-of-the-mill breeds, researchers are learning what it takes to move limbs in a coordinated way. Now, they have pinned down the single genetic mutation that likely causes this peculiar form of locomotion.

Dig into the discovery of antidepressant drugs, how they work, and what we still don’t know about depression.