Loss-of-function genetic screens with pooled sgRNA and shRNA libraries aid in discovery / prioritization of drug targets, understanding of disease progression and gene-disease associations, analysis of signal transduction pathways, characterization of the mechanisms for compounds, uncovering of synergistic gene interactions, and identification of markers of drug resistance and sensitivity. This webinar presents a comparison of loss-of-function genetic screens performed with CRISPR versus RNAi technology.
Loss-of-Function Genetic Screens with RNAi and CRISPR Libraries
Video Oct 06, 2016
Scientists have found a few bones and seven teeth belonging to a previously unknown species of human. They've named the new species Homo luzonensis, after the island of Luzon in the Philippines where it was found. The bones are tiny, suggesting that Homo luzonensis was under 4 feet tall. That would make it the second species of diminutive human to be found in south-east Asia; in 2007 scientists announced the discovery of Homo floresiensis, found on the island of Flores in Indonesia and nicknamed the hobbit. Both species lived around 50,000 years ago, at a time when Asia was also home to our species, the Neanderthals and a group called the Denisovans. The new species raises many questions, including who were its ancestors and how did it move?WATCH NOW