Loss-of-function genetic screens with pooled sgRNA and shRNA libraries aid in discovery / prioritization of drug targets, understanding of disease progression and gene-disease associations, analysis of signal transduction pathways, characterization of the mechanisms for compounds, uncovering of synergistic gene interactions, and identification of markers of drug resistance and sensitivity. This webinar presents a comparison of loss-of-function genetic screens performed with CRISPR versus RNAi technology.
Loss-of-Function Genetic Screens with RNAi and CRISPR Libraries
Video Oct 06, 2016
Professor Sir Doug Turnbull from the Wellcome Trust Centre for Mitochondrial Research at the University of Newcastle explains his research into mitochondrial donation, the innovative treatment that hopes to stop faulty mitochondria being passed on from mother to child to prevent incurable genetic diseases.
The first babies conceived with this treatment through IVF may be born in the UK soon.