The field of organ-on-a-chip has been in existence for 20 years, with the pace of commercialization increasing significantly in the past 5 years. CN Bio Innovations have commercialized single and multi-organ chips based on technology from the lab of Prof L. Griffith at M.I.T. Liver and liver disease models are an attractive target for organ-on-a-chip technologies owing to the relatively rapid dedifferentiation of primary liver cells in 2D culture. In this presentation I will discuss the development and commercialization of CN Bio Innovation’s LiverChip platform together with Quantum B our full viral life cycle model of Hepatitis B infection and look ahead to opportunities for multi-organ systems.