Application of Microfluidic 3D Liver Chip Models for Genotoxity Testing: Go With the Flow
Who's speaking at this Webinar?
Dr. Renato Cardoso
Scientific Director of Genetic Toxicology, Charles River Laboratories (Montreal - Canada)
Dr. Thalita Zanoni
Senior Research Scientist, Charles River Laboratories (Montreal - Canada)
Current in vitro pre-clinical genetic toxicology tools used to determine drug metabolism and genotoxicity consist of a metabolic activation system (induced rat S9 mix) and single cells.
The low concordance between rat and human metabolism is a potential cause for the low predictive power of rat models for human liver toxicity in clinical trials. This webinar will detail the current challenges in the field of integrating microphysiological systems with classic genetic toxicology and will describe advancements made in the Genetic Toxicology Department-Charles River Montreal to successfully tackle these endeavors.
Attend this webinar to learn about:
- Issues of current pre-clinical in vitro drug metabolism and genotoxicity tools and their low predictive power
- Obstacles to integrating novel microphysiological systems with classic genetic toxicology
- Recent advancements to successfully overcome these challenges