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Characterization and Sequence Mapping of mRNA Therapeutics Using Mass Spectrometry

There is currently significant demand for the development of new and improved analytical methods for the characterization of mRNA therapeutics. The ability to rapidly identify, characterize and sequence map large mRNA therapeutics with high sequence coverage provides important information for identity testing, sequence validation and impurity analysis.

In this webinar, we discuss how the development of an automated, high-throughput workflow for the rapid characterization and direct sequence mapping of large RNA and mRNA molecules enables routine comprehensive sequence coverage from a single analysis while overcoming challenges associated with digestion, oligonucleotide separation and identification.

Attend this webinar to learn how to: 

  • Generate large sequence-specific oligonucleotide fragments
  • Achieve high-resolution separation of complex mRNA digests
  • Obtain confident identification of mRNA fragments
  • Streamline data processing and sequence mapping
Mark J. Dickman
Mark J. Dickman
Professor, University of Sheffield