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Detecting Endogenous Nucleotides From Low Numbers of Mammalian Cells


Detecting Endogenous Nucleotides From Low Numbers of Mammalian Cells

Who's speaking at this Webinar?

Rawi Ramautar
Principal Investigator

Biomedical laboratories are under increasing pressure to produce meaningful data from minute amounts of sample. In this webinar, we’ll explore how a micro-scale separation technique, capillary electrophoresis-mass spectrometry (CE-MS), can be used for the highly efficient and sensitive profiling of nucleotides from a low number of mammalian cells.

Endogenous nucleotides can be detected in extracts as low as 500 HepG2 cells. In a research study discussed in this webinar, an injection volume of 6.5 nL resulted in sub-nanomolar detection limits for nucleotides, clearly illustrating the utility of this technique for metabolic profiling in low amounts of biological material.

Attend this webinar to learn:

  • How an electro-driven separation can help detection of endogenous nucleotides with as few as 500 HepG2 cells
  • Review the separation principle and key application areas of capillary electrophoresis-mass spectrometry (CE-MS)
  • Discover the potential of CE-MS for metabolomics studies with limited sample volumes


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