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Expanding the Biologics Toolkit With Next-Generation MALDI Top-Down Sequencing

Next-generation matrix-assisted laser desorption/ionization top-down sequencing (MALDI-TDS) is a highly efficient tool for the characterization of biologics, providing instant information regarding primary sequence, terminal status and near-terminal modifications of protein biotherapeutics.

Next-gen MALDI-TDS analyzes N- and C-terminal MALDI in-source decay (MALDI-ISD) fragments by Trapped Ion Mobility Spectrometry (TIMS) in combination with high-resolution time-of-flight mass spectrometry (TOF-MS).

This webinar will demonstrate the unique capabilities of next-gen MALDI-TDS for in-depth analysis of various pharmaceutical proteins, e.g monoclonal antibodies and viral protein receptor binding domains, and will discuss how the method further expands the biologics toolkit featured by BrukerĀ“s timsTOF fleX ESI/MALDI instrument.

Attend this webinar to learn more about:

  • The benefits of next-gen MALDI-TDS for the characterization of modern biotherapeutics
  • The unique contributions of trapped ion mobility to N- and C-terminal sequencing
  • The timsTOF fleX biologics toolkit integrating ESI and MALDI workflows
Arndt Asperger, PhD
Arndt Asperger, PhD
Senior Applications Scientist Bruker Daltonics, GmbH & Co. KG, Bremen Germany