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Formulating a New Approach to Pharmacokinetics and Cell State Control

Formulating a New Approach to Pharmacokinetics and Cell State Control content piece image

Most in vitro, well-plate biological experiments require a media change every day or two, with cyclic variations in nutrient and metabolite concentrations leading to physiologically unrealistic gene expression and metabolism. Typical step-changes in drug concentrations do not reflect in vitro pharmacokinetic (PK) exposure profiles, which can lead to inaccurate ranking of oncological drug effectiveness. State-of-the-art microfluidic pumps and valves enable the creation of Multi-Well Microformulators that impose on each well a different physiological PK profile, circadian rhythm, or temporal changes of growth factors and signalling molecules. This technology enables dynamic exposure response studies, optimization of stem-cell differentiation, and thousand-channel microchemostats.

Attend this webinar to: 

  • Understand the biological implications of sequential batch feeding of cells in conventional in vitro experiments.
  • Appreciate how microfluidic systems can create a different time-dependent formulation of multiple drugs or other compounds to each well of a multi-well plate.
  • Recognize the opportunity that continuous, controlled media exchange offers for the culture and study of adherent and suspension cells, organoids, and organs-on-chips.
A picture of Professor John Wikswo
Professor John Wikswo
Professor of Biomedical Engineering, Molecular Physiology & Biophysics, and Physics Vanderbilt University