Latest Applications of 4D-Proteomics using the timsTOF Pro and recent developments in ultra-high sensitivity applications

These talks from Brurker Daltonics will discuss the PASEF, dia-PASEF and prm-PASEF methods, and how these methods allow researchers to perform proteomics faster, with better depth of coverage. They will also discuss new, high-performance technologies for improving spatial resolution, sensitivity and specificity of MALDI IMS. Both talks will cover some of the latest applications of these methods and technologies.

Key points of Gary's discussion: 

• Summary of PASEF, dia-PASEF and prm-PASEF methods
• The latest applications of the timsTOF Pro and 4D-proteomics technology to biomarker discovery and validation, immunopeptidomcs and other ultrahigh sensitivity applications.

Key points of Jeffrey Spraggins's discussion:

• Highlight work in developing new, high-performance technologies for improving spatial resolution, sensitivity and specificity of MALDI IMS.
• Recent advances in integrated, multimodal methods that enable molecular signals to be paired to specific biological tissue features.