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Liver-on-Chip and In Silico Modeling for Quantitative Drug Metabolism Studies

Liver-on-Chip and <i>In Silico</i> Modeling for Quantitative Drug Metabolism Studies content piece image

Understanding the pharmacokinetics (PK) of new drugs has typically relied quite heavily on animal models, however, these models are expensive and often have limited relevance to humans. The development of a Liver-on-a-Chip (LOAC) device, that better recapitulates human physiology compared to standard in vitro systems, represents a promising alternative to reduce the use of animal models.

This webinar will examine the benefits of combining LOAC with in silico modeling to explore clinical PK predictions of specific reference drugs, including investigations into the intrinsic clearance determinations for high metabolically stable compounds and the quantitation of fractions metabolized by specific enzymes.

Attend this webinar to learn about:

  • Various applications of Liver-on-a-Chip in quantitative PK
  • CYP (Cytochrome P450) and UGT (Uridine Diphosphate-glucuronosyltransferase) metabolism with Liver-on-a-Chip
  • Combining in silico modeling and experimental data for in vitro–in vivo extrapolation
  • Liver-on-a-Chip and future perspectives
Dr Nicolo Milani
Dr Nicolo Milani
Postdoc Scientist, Hoffmann-La Roche, Basel Switzerland