Genomic tools for Psilocybe cubensis propagation
Kevin McKernan, CSO at Medicinal Genomics will be joining us to discuss genetic variation in the Psilocybe cubensis synthesis pathway and the design of qPCR assays for simultaneous quantification of E. coli and Salmonella species contamination concurrent with Psilocybe cubensis species identification.
Exploiting the timsTOF and MALDI-2 Platforms to Assess Pharmacodynamics and Pharmacokinetics in Preclinical Models
An integrated evaluation of the pharmacodynamic and pharmacokinetic properties of a drug is essential for successful translation to the clinic. However, cost-effective methods to measure these parameters at the systems level in pre-clinical models are lacking. Here, we introduce a timsTOF and MALDI-2 workflow to evaluate therapeutic activity. The platform combines ion mobility, mass spectrometry-based imaging, absolute drug quantitation across different biological matrices, in vivo isotope tracing, and global metabolome analysis in the adult zebrafish.
Scaling Non-Viral Cell Therapy Approaches for Solid Tumor Treatments
In this webinar, speakers from PACT Pharma Inc. and Thermo Fisher Scientific discuss how modular instrumentation platforms can enable automation and standardization of the end-to-end manufacturing workflow, from cell isolation and activation to genetic modification and expansion.
Effective Nuclei Isolation From Tissue for Single-Nucleus Sequencing
In this webinar, we present a standardized workflow solution, including easy and automated nuclei extraction and isolation for reproducible single-nucleus sequencing analysis.
Predictive Toxicology: Organ-Chips Demonstrate Superior Performance to Animal Models and Spheroids
To explore how this challenge might be approached, 780 human Liver-Chips were analyzed to determine their ability to predict drug-induced liver injury caused by small molecules.
Explore Rapid Assembly of Gene Fragments Using Enzymatic DNA Synthesis
Nelly Lourenço, from DNA Script will discuss how oligos on demand can accelerate innovation by effectively enabling assembly of the full 720bp GFP gene using EDS oligos via polymerase chain assembly.