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Latest Whitepapers

Flasks
Whitepaper

UHPLC-MS Grade Solvents for Trace Level Analysis and Research Method Assays

Ultra-high performance liquid chromatography (UHPLC) involves utilizing columns with submicron-sized particles and high-pressure flow, resulting in enhanced resolution and sensitivity when dealing with complex sample mixtures. Mass spectrometry (MS) plays a vital role in detecting and identifying analytes even at concentrations as low as parts per trillion.
Mobile Phase Liquid Chrom
Whitepaper

Optimizing Mobile Phase Solvent Purity for LC-MS

Liquid chromatography mass spectrometry (LC-MS) plays a pivotal role in the precise analysis of trace molecules. To enhance sensitivity and accuracy, it is crucial for researchers to upgrade from HPLC-grade solvents to LC-MS grade solvents that are specially designed to meet the stringent requirements of modern LC-MS systems.
Virus
Whitepaper

Discover Biolayer Interferometry as an AAV Analytics Solution

Adeno-associated viral vector (AAV) has become a preferred gene therapy delivery modality; however, AAV manufacturing is not without its challenges, whether that is using crude samples, a lack of standardized methods or incompatible techniques.
Virus
Whitepaper

A Breakthrough Solution for AAV Manufacturing Challenges

Despite the success of AAV for gene therapies and vaccines, many challenges still exist within AAV manufacturing. To ensure the safety and efficacy of a therapeutic, it is crucial to accurately determine the percentage of capsids that carry the gene of interest.
Benefits of AGT Culture Media in Gene Therapy Applications content piece image
Whitepaper

Benefits of AGT Culture Media in Gene Therapy Applications

A scalable and robust solution for all stages of the gene therapy workflow to meet regulatory standards is essential, however, as the field is more recent, liquid media is the common format even though it can be more expensive and have a shorter shelf life.
Lab Machinery
Whitepaper

Maximizing Scale Up: Critical Considerations for Buffer Preparation

Whether scaling up production in-house or using a contractor there are many factors to consider. This whitepaper outlines how outsourcing process development to an experienced provider can improve workflow efficiency and reduce overall costs.
Drug Conjugates
Whitepaper

Antibody–Drug Conjugates: A Novel Paradigm for Cancer Therapy

This whitepaper highlights the key molecular components of ADCs and the challenges and opportunities for their future development.
Tumor Microenvironment
Whitepaper

Enhanced CD8+ T Cell Isolation From Mouse Tumors: SimpleFlow vs Enzymatic Methods

Tissue dissociation is a crucial sample preparation step that enables the isolation of specific cell populations for downstream applications such as single-cell RNA sequencing. Enzymatic tissue dissociation is widely used, but some researchers have concerns about the impact of enzymes on cell marker expression.
The mRNA Therapeutics Boom
Whitepaper

The Power of mRNA in Accelerating Therapeutic Development

mRNA-based therapies, from infectious disease vaccines to genetic disorder treatments, are gaining traction. However, mRNA purification methods must evolve beyond traditional precipitation techniques to meet the demands of large-scale therapeutic production.
Neuro mapping
Whitepaper

Enhanced Mouse Brain Cell Surface Expression – A Comparison to Enzymatic Methods

As researchers endeavor to map the architecture of the brain, many rely on tissue dissociation approaches to prepare single-cell suspensions for downstream analysis. Howev er, such conventional methods can involve enzymes and heat, which are known to induce transcriptional and proteotype changes in brain cells.
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