Novel Plasticware for Three-Dimensional (3D) Cell Co-culture

A paradigm shift from two-dimensional (2D) to 3D cell culture techniques1 has grown rapidly in recent years2. A shift from traditional monolayer culture to 3D affects cell function and behavior including morphology3, gene expression4 and similarity to the in vivo response5. To date, the majority of related research and commercial activity has focused on novel 3D scaffolds utilized in traditional 2D plastic ware. Innovative 3D plasticware is needed to accommodate the spectrum of 3D scaffold configurations and materials, provide dynamic fluid medium exchange to sustain long-term cell viability and function, synergy with advanced imaging modalities, advanced co-culture of multiple cell types, and cost-effective.